Integrins are cell adhesion receptors, which are typically transmembrane glycoproteins that
connect to the extracellular matrix (ECM). The function of integrins regulated by biochemical …

The matrix metalloproteinases (MMPs) form an enzyme family of which gelatinase B (MMP-
9) represents the largest and most complex member. We focus here on the biochemical …

Tumors are composed of multiple cell types besides the tumor cells themselves, including
innate immune cells such as macrophages. Tumor-associated macrophages (TAMs) are a …

Background Cancer cell resistance to therapeutics can result from acquired or de novo-
mediated factors. Here, we have utilised advanced breast cancer cell culture models to …

Cancer cell invasion into healthy tissues develops preferentially along pre‐existing tracks of
least resistance, followed by secondary tissue remodelling and destruction. The tissue …

Ischemia-reperfusion injury (IRI) is the main cause of morbidity and mortality due to graft
rejection after liver transplantation. During IRI, an intense inflammatory process occurs in the …

The matrix metalloproteinases (MMP)-2 and-9, also known as the gelatinases have been
long recognized as major contributors to the proteolytic degradation of extracellular matrix …

Cancer is one of the major and leading causes of death worldwide. Two of the greatest
challenges in fighting cancer are early detection and effective treatments with no or …

Epithelial-Mesenchymal Transition (EMT) is a critical process in embryonic development in
which epithelial cells undergo a transdifferentiation into mesenchymal cells. This process is …

Cancer is the final result of uninhibited cell growth that involves an enormous group of
associated diseases. One major aspect of cancer is when cells attack adjacent components …