Adaptive immunity, orchestrated by B-cells and T-cells, plays a crucial role in protecting the
body from pathogenic invaders and can be used as tools to enhance the body's defense …

Tumor immunotherapy, particularly the use of immune checkpoint inhibitors, has yielded
impressive clinical benefits. Therefore, it is critical to accurately screen individuals for …

BACKGROUND. T cells expressing antigen-specific chimeric antigen receptors (CARs)
improve outcomes for CD19-expressing B cell malignancies. We evaluated a human …

BACKGROUND Chimeric antigen receptor (CAR) T cell immunotherapy has resulted in
complete remission (CR) and durable response in highly refractory patients. However …

Abstract The Sleeping Beauty (SB) transposon is a promising technology platform for gene
transfer in vertebrates; however, its efficiency of gene insertion can be a bottleneck in …

Medulloblastoma, the most common malignant paediatric brain tumour, arises in the
cerebellum and disseminates through the cerebrospinal fluid in the leptomeningeal space to …

The medaka fish Tol2 element is an autonomous transposon that encodes a fully functional
transposase. The transposase protein can catalyze transposition of a transposon construct …

Infusions of antigen-specific T cells have yielded therapeutic responses in patients with
pathogens and tumors. To broaden the clinical application of adoptive immunotherapy …

Transposons are mobile genetic elements that can be used to integrate transgenes into host
cell genomes. The piggyBac transposon system has been used for transgenesis of insects …

Genetically engineered mouse models have significantly contributed to our understanding of
cancer biology. They have proven to be useful in validating gene functions, identifying novel …