Sleep-wake disturbances after traumatic brain injury: synthesis of human and animal studies

DK Sandsmark, JE Elliott, MM Lim - Sleep, 2017 - academic.oup.com
Sleep–wake disturbances following traumatic brain injury (TBI) are increasingly recognized
as a serious consequence following injury and as a barrier to recovery. Injury-induced sleep …

The bidirectional relationship between sleep and inflammation links traumatic brain injury and Alzheimer's disease

TRF Green, JB Ortiz, S Wonnacott… - Frontiers in …, 2020 - frontiersin.org
Traumatic brain injury (TBI) and Alzheimer's disease (AD) are diseases during which the fine-
tuned autoregulation of the brain is lost. Despite the stark contrast in their causal …

Rod microglia: a morphological definition

SE Taylor, C Morganti-Kossmann, J Lifshitz, JM Ziebell - PloS one, 2014 - journals.plos.org
Brain microglial morphology relates to function, with ramified microglia surveying the micro-
environment and amoeboid microglia engulfing debris. One subgroup of microglia, rod …

Resolvins AT-D1 and E1 differentially impact functional outcome, post-traumatic sleep, and microglial activation following diffuse brain injury in the mouse

JL Harrison, RK Rowe, TW Ellis, NS Yee… - Brain, behavior, and …, 2015 - Elsevier
Traumatic brain injury (TBI) is induced by mechanical forces which initiate a cascade of
secondary injury processes, including inflammation. Therapies which resolve the …

Glial immune-related pathways mediate effects of closed head traumatic brain injury on behavior and lethality in Drosophila

B van Alphen, S Stewart, M Iwanaszko, F Xu, K Li… - PLoS …, 2022 - journals.plos.org
In traumatic brain injury (TBI), the initial injury phase is followed by a secondary phase that
contributes to neurodegeneration, yet the mechanisms leading to neuropathology in vivo …

The effect of traumatic brain injury on sleep architecture and circadian rhythms in mice—a comparison of high-frequency head impact and controlled cortical injury

HT Korthas, BS Main, AC Harvey, RG Buenaventura… - Biology, 2022 - mdpi.com
Simple Summary Traumatic brain injury (TBI) is a significant risk factor for the development
of sleep and circadian rhythm impairments. In order to understand if TBI models with …

Clinical relevance of midline fluid percussion brain injury: acute deficits, chronic morbidities and the utility of biomarkers

J Lifshitz, RK Rowe, DR Griffiths, MN Evilsizor… - Brain injury, 2016 - Taylor & Francis
Background: After 30 years of characterisation and implementation, fluid percussion injury
(FPI) is firmly recognised as one of the best-characterised reproducible and clinically …

Roadmap for advancing pre-clinical science in traumatic brain injury

DH Smith, PM Kochanek, S Rosi, R Meyer… - Journal of …, 2021 - liebertpub.com
Pre-clinical models of disease have long played important roles in the advancement of new
treatments. However, in traumatic brain injury (TBI), despite the availability of numerous …

Sleep disruption exacerbates and prolongs the inflammatory response to traumatic brain injury

ZM Tapp, JE Kumar, KG Witcher, RR Atluri… - Journal of …, 2020 - liebertpub.com
Traumatic brain injury (TBI) alters stress responses, which may influence neuroinflammation
and behavioral outcome. Sleep disruption (SD) is an understudied post-injury environmental …

Many faces of sleep regulation: beyond the time of day and prior wake time

JM Duhart, S Inami, K Koh - The FEBS journal, 2023 - Wiley Online Library
The two‐process model of sleep regulation posits two main processes regulating sleep: the
circadian process controlled by the circadian clock and the homeostatic process that …