Natural product research aims to characterize specialized metabolites from various living
organisms and assess their biological properties from either a chemical ecology or drug …

The proteome, or collection of proteoforms expressed in a biological system, is dynamic and
heterogeneous. As our appreciation for the complexity of the proteome has evolved, so have …

A production prototype structures for lossless ion manipulation ion mobility (SLIM IM)
platform interfaced to a commercial high-resolution mass spectrometer (MS) is described …

A new instrument configuration for native ion mobility-mass spectrometry (IM-MS) is
described. Macromolecule ions are generated by using a static ESI source coupled to an RF …

The structural diversity of phospholipids plays a critical role in cellular membrane dynamics,
energy storage, and cellular signaling. Despite its importance, the extent of this diversity has …

Charge detection mass spectrometry (CD-MS) enables characterization of large,
heterogeneous analytes through the analysis of individual ion signals. Because hundreds to …

In recent years, metabolomics and lipidomics approaches have become increasingly
popular for use in the analysis of human heath, molecular mechanisms, and disease …

Ion mobility spectrometry coupled to mass spectrometry (IMS-MS) is slowly becoming a
more integral part in omics-based workflows. With the recent technological advancements in …

Described herein is the development of a 3D-printed drift-tube ion mobility spectrometer
(IMS) which operates in the open air and is capable of being coupled to any mass …

New developments in analytical technologies and biophysical methods have advanced the
characterization of increasingly complex biomolecular assemblies using native mass …