Fitness costs of plasmids: a limit to plasmid transmission
A San Millan, RC MacLean - Microbiology spectrum, 2017 - Am Soc Microbiol
Plasmids mediate the horizontal transmission of genetic information between bacteria,
facilitating their adaptation to multiple environmental conditions. An especially important …
facilitating their adaptation to multiple environmental conditions. An especially important …
Translation elongation and recoding in eukaryotes
In this review, we highlight the current understanding of translation elongation and recoding
in eukaryotes. In addition to providing an overview of the process, recent advances in our …
in eukaryotes. In addition to providing an overview of the process, recent advances in our …
Design, synthesis, and testing toward a 57-codon genome
Recoding—the repurposing of genetic codons—is a powerful strategy for enhancing
genomes with functions not commonly found in nature. Here, we report computational …
genomes with functions not commonly found in nature. Here, we report computational …
An integrated, structure-and energy-based view of the genetic code
H Grosjean, E Westhof - Nucleic acids research, 2016 - academic.oup.com
The principles of mRNA decoding are conserved among all extant life forms. We present an
integrative view of all the interaction networks between mRNA, tRNA and rRNA: the intrinsic …
integrative view of all the interaction networks between mRNA, tRNA and rRNA: the intrinsic …
What is code biology?
M Barbieri - Biosystems, 2018 - Elsevier
Various independent discoveries have shown that many organic codes exist in living
systems, and this implies that they came into being during the history of life and contributed …
systems, and this implies that they came into being during the history of life and contributed …
Biocatalysis with unnatural amino acids: enzymology meets xenobiology
F Agostini, JS Völler, B Koksch… - Angewandte Chemie …, 2017 - Wiley Online Library
The goal of xenobiology is to design biological systems endowed with unusual biochemical
functions, whereas enzymology concerns the study of enzymes, the workhorses of …
functions, whereas enzymology concerns the study of enzymes, the workhorses of …
Origin and evolution of the universal genetic code
EV Koonin, AS Novozhilov - Annual review of genetics, 2017 - annualreviews.org
The standard genetic code (SGC) is virtually universal among extant life forms. Although
many deviations from the universal code exist, particularly in organelles and prokaryotes …
many deviations from the universal code exist, particularly in organelles and prokaryotes …
Transfer RNAs: diversity in form and function
As the adaptor that decodes mRNA sequence into protein, the basic aspects of tRNA
structure and function are central to all studies of biology. Yet the complexities of their …
structure and function are central to all studies of biology. Yet the complexities of their …
Rewriting the genetic code
The genetic code—the language used by cells to translate their genomes into proteins that
perform many cellular functions—is highly conserved throughout natural life. Rewriting the …
perform many cellular functions—is highly conserved throughout natural life. Rewriting the …
Mechanisms of protein evolution
How do proteins evolve? How do changes in sequence mediate changes in protein
structure, and in turn in function? This question has multiple angles, ranging from …
structure, and in turn in function? This question has multiple angles, ranging from …