IGF1R as druggable target mediating PI3K-δ inhibitor resistance in a murine model of chronic lymphocytic leukemia
A Scheffold, BMC Jebaraj, E Tausch… - Blood, The Journal …, 2019 - ashpublications.org
Targeted therapy is revolutionizing the treatment of cancers, but resistance evolves against
these therapies and derogates their success. The phosphatidylinositol 3-kinase delta (PI3K …
these therapies and derogates their success. The phosphatidylinositol 3-kinase delta (PI3K …
A dominant-negative FGF1 mutant (the R50E mutant) suppresses tumorigenesis and angiogenesis
S Mori, V Tran, K Nishikawa, T Kaneda, Y Hamada… - PloS one, 2013 - journals.plos.org
Fibroblast growth factor-1 (FGF1) and FGF2 play a critical role in angiogenesis, a formation
of new blood vessels from existing blood vessels. Integrins are critically involved in FGF …
of new blood vessels from existing blood vessels. Integrins are critically involved in FGF …
Crosstalk between fibroblast growth factor (FGF) receptor and integrin through direct integrin binding to FGF and resulting integrin-FGF-FGFR ternary complex …
S Mori, Y Takada - Medical Sciences, 2013 - mdpi.com
Fibroblast growth factors (FGFs) play a critical role in diverse physiological processes and
the pathogenesis of diseases. Integrins are involved in FGF signaling, since integrin …
the pathogenesis of diseases. Integrins are involved in FGF signaling, since integrin …
Cell-surface proteomics identifies differences in signaling and adhesion protein expression between naive and primed human pluripotent stem cells
K Wojdyla, AJ Collier, C Fabian, PS Nisi, L Biggins… - Stem Cell Reports, 2020 - cell.com
Naive and primed human pluripotent stem cells (hPSC) provide valuable models to study
cellular and molecular developmental processes. The lack of detailed information about cell …
cellular and molecular developmental processes. The lack of detailed information about cell …
Proinflammatory secreted phospholipase A2 type IIA (sPLA-IIA) induces integrin activation through direct binding to a newly identified binding site (site 2) in integrins …
Integrins are activated by signaling from inside the cell (inside-out signaling) through global
conformational changes of integrins. We recently discovered that fractalkine activates …
conformational changes of integrins. We recently discovered that fractalkine activates …
IGF-IR Promotes Prostate Cancer Growth by Stabilizing α5β1 Integrin Protein Levels
Dynamic crosstalk between growth factor receptors, cell adhesion molecules and
extracellular matrix is essential for cancer cell migration and invasion. Integrins are …
extracellular matrix is essential for cancer cell migration and invasion. Integrins are …
[PDF][PDF] and Peter J. Rugg-Gunn
K Wojdyla, AJ Collier, C Fabian, PS Nisi, L Biggins… - babraham.ac.uk
Naive and primed human pluripotent stem cells (hPSC) provide valuable models to study
cellular and molecular developmental processes. The lack of detailed information about cell …
cellular and molecular developmental processes. The lack of detailed information about cell …
[图书][B] A novel function for 12-lipoxygenase in c-Met and integrin β4 axis crosstalk
E Tovar - 2014 - search.proquest.com
Cancer cell metastasis is the single most threatening occurrence of tumor progression and
predicts patient prognosis as well as survival. Invasion can be regulated by the Met receptor …
predicts patient prognosis as well as survival. Invasion can be regulated by the Met receptor …