Dysregulated neutrophil activation contributes to the pathogenesis of autoimmune diseases
including rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). Neutrophil …

Systemic lupus erythematosus (SLE) is a chronic, systemic autoimmune disease that causes
damage to multiple organ systems. Despite decades of research and available murine …

Neutrophil dysregulation is implicated in the pathogenesis of systemic lupus erythematosus
(SLE). SLE is characterized by elevated levels of a pathogenic neutrophil subset known as …

SARS-CoV2 is a previously uncharacterized coronavirus and causative agent of the COVID-
19 pandemic. The host response to SARS-CoV2 has not yet been fully delineated …

Vascular pathologies underpin and intertwine autoimmune rheumatic diseases and
cardiovascular conditions, and atherosclerosis is increasingly recognized as the leading …

The contribution of dyslipidemia and inflammation in atherosclerosis is well established.
Along with effective lipid-lowering treatments, the recent success of clinical trials with anti …

Polymorphonuclear neutrophils (PMNs) are traditionally regarded as professional
phagocytic and acute inflammatory cells that engulf the microbial pathogens. However …

A body of evidence has re‐energized the interest on the role neutrophils in inflammatory and
autoimmune conditions. For decades, neutrophils have been considered a homogenous …

Objectives Low-density granulocytes (LDGs) are a distinct subset of proinflammatory and
vasculopathic neutrophils expanded in systemic lupus erythematosus (SLE). Neutrophil …

Gene expression signatures can stratify patients with heterogeneous diseases, such as
systemic lupus erythematosus (SLE), yet understanding the contributions of ancestral …