Abstract The phosphatidylinositol-3-kinase (PI3K)/AKT pathway is a major regulator of
metabolism, migration, survival, proliferation, and antiviral immunity. Both an overactivation …

Myocardial infarction is a prevalent and life-threatening cardiovascular disease. The main
goal of existing interventional therapies is to restore coronary reperfusion while few are …

Abstract The E3 SUMO ligase PIAS2 is expressed at high levels in differentiated papillary
thyroid carcinomas but at low levels in anaplastic thyroid carcinomas (ATC), an …

Alpha-fetoprotein (AFP) is the most widely used biomarker for the diagnosis of
hepatocellular carcinoma (HCC). However, a substantial proportion of HCC patients have …

The SUMO family is a type of ubiquitin-like protein modification molecule. Its protein
modification mechanism is similar to that of ubiquitination: both involve modifier-activating …

Simple Summary BCAS1-SV1, a novel splice variant of BCAS1, promotes the proliferation
and migration of glioblastoma cells by directly binding to and inhibiting the tumor suppressor …

Primary malignant melanoma of the esophagus (PMME) is an exceedingly rare disease with
a poor prognosis. The etiology of PMME remains largely unknown and genetic …

β‐arrestin2, a member of the arrestin family, mediates the desensitization and internalization
of most G protein‐coupled receptors (GPCRs) and functions as a scaffold protein in …

Abstract Ran GTPase activating protein 1 (RanGAP1) has been implicated in various
diseases, but its role in colorectal cancer (CRC) progression remains unclear. Using tumor …

C9orf72‐derived dipeptide repeats (DPRs) proteins have been regarded as the pathogenic
cause of neurodegeneration in amyotrophic lateral sclerosis and frontotemporal dementia …