Translational medicine aims to improve human health by exploring potential treatment
methods developed during basic scientific research and applying them to the treatment of …

Flaviviruses comprise several important human pathogens which cause significant morbidity
and mortality worldwide. Like any other virus, they are obligate intracellular parasites …

It is unclear how the activation of HIV-1 transcription affects chromatin structure. We
interrogated chromatin organization both genome-wide and nearby HIV-1 integration sites …

The long-term goal of scientists and breeders is to study the efficacy of a gene, as well as to
use it in the development of human life and in the development of improved quality and …

abstract The high mutation rate of SARS-CoV-2 leads to the emergence of multiple variants,
some of which are resistant to vaccines and drugs targeting viral elements. Targeting host …

Loss-of-function and gain-of-function genetic perturbations provide valuable insights into
gene function. In Drosophila cells, while genome-wide loss-of-function screens have been …

ABSTRACT CRISPR Cas system is a revolutionary and precise genome editing system that
induces bacterial and archaeal adaptive immunity and already has shown several promising …

Concurrent use of substance such as alcohol and anti-HIV drugs is increasing in people with
HIV (PWH) due to the pandemic and social isolation, 1, 2 which further weakens the immune …

The recent pandemic has reminded the public that basic research in virology is pivotal for
human health. Understanding the mechanisms of successful viral replication and the role of …