Structural chromosomal rearrangements result from different mechanisms of formation,
usually related to certain genomic architectural features that may lead to genetic instability …

The human genome is generally organized into stable chromosomes, and only tumor cells
are known to accumulate kilobase (kb)-sized extrachromosomal circular DNA elements …

Background Much interest has not been placed on the role of chromosomal abnormalities in
the pathogenesis and rising prevalence of infertility in recent times. This review was …

Here, we report the design, construction, and characterization of a tRNA neochromosome, a
designer chromosome that functions as an additional, de novo counterpart to the native …

Extrachromosomal circular DNA (eccDNA) and ring chromosomes are genetic alterations
found in humans with genetic disorders. However, there is a lack of genetic engineering …

Chromosome-derived extrachromosomal circular DNA elements (eccDNAs) are detected in
all eukaryotes examined so far. Here I describe the Circle-Seq protocol, applicable for …

To explore the presence of extrachromosomal circular DNA (eccDNA) in the anterior
capsule of the lens in the eyes of patients with cataract and with high myopia. Circle-Seq …

Inverted duplications are a common type of copy number variation (CNV) in germline and
somatic genomes. Large duplications that include many genes can lead to both …

Human ring chromosomes are often unstable during mitosis, and daughter cells can be
partially or completely aneuploid. We studied the mitotic stability of four ring chromosomes …

Ring chromosomes (RCs) are circular DNA molecules, which occur rarely in eukaryotic
nuclear genomes. Lilian Vaughan Morgan first described them in the fruit fly. Human …