Helicases and translocases are a ubiquitous, highly diverse group of proteins that perform
an extraordinary variety of functions in cells. Consequently, this review sets out to define a …

Crystallography supplies unparalleled detail on structural information critical for mechanistic
analyses; however, it is restricted to describing low energy conformations of …

Complex cellular events commonly depend on the activity of molecular “machines” that
efficiently couple enzymatic and regulatory functions within a multiprotein assembly. An …

The AAA+ ATPases are enzymes containing a P-loop NTPase domain, and function as
molecular chaperones, ATPase subunits of proteases, helicases or nucleic-acid-stimulated …

Cellular DNA replication is initiated through the action of multiprotein complexes that
recognize replication start sites in the chromosome (termed origins) and facilitate duplex …

Structural information on helicase proteins has expanded recently beyond the DNA
helicases Rep and PcrA, and the hepatitis C virus RNA helicase to include UvrB, members …

Members of the diverse superfamily of AAA+ proteins are molecular machines responsible
for a wide range of essential cellular processes. In this review we summarise structural and …

Using sequence profile analysis and sequence-based structure predictions, we define a
previously unrecognized, widespread class of P-loop NTPases. The signal transduction …

Objective The cryopyrinopathies are a group of rare autoinflammatory disorders that are
caused by mutations in CIAS1, encoding the cryopyrin protein. However, cryopyrin …

The Holliday junction is a key intermediate formed during DNA recombination across all
kingdoms of life. In bacteria, the Holliday junction is processed by two homo-hexameric …