Breast cancer is the quintessential example of how molecular characterization of tumor
biology guides therapeutic decisions. From the discovery of the estrogen receptor to current …

Breast cancer is one of the major causes of mortality in women worldwide. The most
aggressive breast cancer subtypes are human epidermal growth factor receptor-positive …

MicroRNAs play important roles in many biological processes. Their aberrant expression
can have oncogenic or tumor suppressor function directly participating to carcinogenesis …

The NanoLuc luciferase (NLuc) and its furimazine (FRZ) substrate have revolutionized
bioluminescence (BL) assays and imaging. However, the use of the NLuc–FRZ luciferase …

Purpose Triple-negative breast cancer (TNBC) is the most aggressive breast cancer
subgroup characterized by a high risk of resistance to chemotherapies and high relapse …

Breast cancer (BC) is the most prevalent type of cancer in women in western countries. BC
mortality has not declined despite early detection by screening, indicating the need for better …

HER2-positive breast cancers may lose HER2 expression in recurrences and metastases. In
this work, we studied cell lines derived from two transgenic mammary tumors driven by …

Breast cancers are known to be driven by the transcription factor estrogen receptor and its
ligand estrogen. While the receptor's cis-binding elements are known to vary between …

Background: The lack of molecular targets for triple negative breast cancer (TNBC) has
limited treatment options and reduced survivorship. Identifying new molecular targets may …

Breast cancer cells that have undergone partial epithelial–mesenchymal transition (EMT)
are believed to be more invasive than cells that have completed EMT. To study metabolic …