Alterations in cardiac energy metabolism contribute to the severity of heart failure. However,
the energy metabolic changes that occur in heart failure are complex and are dependent not …

The heart consumes large amounts of energy in the form of ATP that is continuously
replenished by oxidative phosphorylation in mitochondria and, to a lesser extent, by …

To maintain its high energy demand the heart is equipped with a highly complex and
efficient enzymatic machinery that orchestrates ATP production using multiple energy …

Diabetes mellitus-related cardiomyopathy (DMCMP) was originally described as a dilated
phenotype with eccentric left ventricular (LV) remodelling and systolic LV dysfunction …

The heart has a high rate of ATP production and turnover that is required to maintain its
continuous mechanical work. Perturbations in ATP-generating processes may therefore …

The network for cardiac fuel metabolism contains intricate sets of interacting pathways that
result in both ATP-producing and non–ATP-producing end points for each class of energy …

The heart utilizes large amounts of fatty acids as energy providing substrates. The
physiological balance of lipid uptake and oxidation prevents accumulation of excess lipids …

Heart disease is a leading cause of death worldwide. In many forms of heart disease,
including heart failure, ischaemic heart disease and diabetic cardiomyopathies, changes in …

The heart has both the greatest caloric needs and the most robust oxidation of fatty acids
(FAs). Under pathological conditions such as obesity and type 2 diabetes, cardiac uptake …

Cardiac metabolism is vital for heart function. Given that cardiac contraction requires a
continuous supply of ATP in large quantities, the role of fuel metabolism in the heart has …