Genomic imprinting affects several dozen mammalian genes and results in the expression of
those genes from only one of the two parental chromosomes. This is brought about by …

Germ cells may be defined as those cells, all of whose surviving descendants will become
sperm or eggs. In all sexually reproducing animals and plants, these cells play a uniquely …

We have previously shown that pluripotent stem cells can be induced from mouse fibroblasts
by retroviral introduction of Oct3/4 (also called Pou5f1), Sox2, c-Myc and Klf4, and …

Overfeeding and overeating in families are traditions that are often transferred from
generation to generation. Irrespective of these family traditions, food availability might lead …

Abstract Inhibitors of Mek1/2 and Gsk3β, known as 2i, enhance the derivation of embryonic
stem (ES) cells and promote ground-state pluripotency in rodents,. Here we show that the …

Cloning of mammals by nuclear transfer (NT) results in gestational or neonatal failure with at
most a few percent of manipulated embryos resulting in live births. Many of those that …

Social circumstances often impinge on later generations in a socio-economic manner, giving
children an uneven start in life. Overfeeding and overeating might not be an exception. The …

Imprinted genes are differentially marked during germ cell development to allow for their
eventual parent-of-origin specific expression. A subset of imprinted genes becomes …

Superovulation or ovarian stimulation is currently an indispensable assisted reproductive
technology (ART) for human subfertility/infertility treatment. Recently, increased frequencies …

Most cells contain the same set of genes and yet they are extremely diverse in appearance
and functions. It is the selective expression and repression of genes that determines the …