Reprogramming dendritic cells through the immunological synapse: a two‐way street

D Calzada‐Fraile… - European Journal of …, 2023 - Wiley Online Library
Dendritic cells (DCs) bridge innate and adaptive immunity. Their main function is to present
antigens to prime T cells and initiate and shape adaptive responses. Antigen presentation …

Crosstalk between T lymphocytes and dendritic cells

C Hivroz, K Chemin, M Tourret… - Critical Reviews™ in …, 2012 - dl.begellhouse.com
Dendritic cells (DCs) are professional antigen-presenting cells (APCs) with the unique
property of inducing priming and differentiation of naïve CD4+ and CD8+ T cells into helper …

Priming of dendritic cells by DNA-containing extracellular vesicles from activated T cells through antigen-driven contacts

D Torralba, F Baixauli, C Villarroya-Beltri… - Nature …, 2018 - nature.com
Interaction of T cell with antigen-bearing dendritic cells (DC) results in T cell activation, but
whether this interaction has physiological consequences on DC function is largely …

Mechanisms of CD40-dependent cDC1 licensing beyond costimulation

R Wu, RA Ohara, S Jo, TT Liu, ST Ferris, F Ou… - Nature …, 2022 - nature.com
CD40 signaling in classical type 1 dendritic cells (cDC1s) is required for CD8 T cell-
mediated tumor rejection, but the underlying mechanisms are incompletely understood …

FoxO1 regulates Tlr4 inflammatory pathway signalling in macrophages

WQ Fan, H Morinaga, JJ Kim, E Bae, NJ Spann… - The EMBO …, 2010 - embopress.org
The macrophage‐mediated inflammatory response is a key etiologic component of obesity‐
related tissue inflammation and insulin resistance. The transcriptional factor FoxO1 is a key …

Immune synapse formation promotes lipid peroxidation and MHC-I upregulation in licensed dendritic cells for efficient priming of CD8+ T cells

D Calzada-Fraile, S Iborra, M Ramírez-Huesca… - Nature …, 2023 - nature.com
Antigen cognate dendritic cell (DC)-T cell synaptic interactions drive activation of T cells and
instruct DCs. Upon receiving CD4+ T cell help, post-synaptic DCs (psDCs) are licensed to …

Nuclear translocation of AMPK-α1 potentiates striatal neurodegeneration in Huntington's disease

TC Ju, HM Chen, JT Lin, CP Chang, WC Chang… - Journal of Cell …, 2011 - rupress.org
Adenosine monophosphate–activated protein kinase (AMPK) is a major energy sensor that
maintains cellular energy homeostasis. Huntington's disease (HD) is a neurodegenerative …

Nanostructured lipid carrier mediates effective delivery of methotrexate to induce apoptosis of rheumatoid arthritis via NF-κB and FOXO1

NK Garg, RK Tyagi, B Singh, G Sharma… - International journal of …, 2016 - Elsevier
Present study was designed to develop novel nano-structured lipid carriers (NLCs)
formulated by lipid mixture and chemical permeation enhancer-based hydrogel for an …

Quercetin inhibited LPS-induced cytokine storm by interacting with the AKT1-FoxO1 and Keap1-Nrf2 signaling pathway in macrophages

J Xu, Y Li, X Yang, H Li, X Xiao, J You, H Li, L Zheng… - Scientific Reports, 2024 - nature.com
Cytokine storm (CS) emerges as an exacerbated inflammatory response triggered by
various factors such as pathogens and excessive immunotherapy, posing a significant threat …

Transfer of extracellular vesicle‐micro RNA controls germinal center reaction and antibody production

L Fernández‐Messina, A Rodríguez‐Galán… - EMBO …, 2020 - embopress.org
Intercellular communication orchestrates effective immune responses against disease‐
causing agents. Extracellular vesicles (EVs) are potent mediators of cell–cell …