[HTML][HTML] Building models of brain disorders with three-dimensional organoids
Disorders of the nervous system are challenging to study and treat due to the relative
inaccessibility of functional human brain tissue for research. Stem cell-derived 3D human …
inaccessibility of functional human brain tissue for research. Stem cell-derived 3D human …
[HTML][HTML] The long-term restoration of ecosystem complexity
Multiple large-scale restoration strategies are emerging globally to counteract ecosystem
degradation and biodiversity loss. However, restoration often remains insufficient to offset …
degradation and biodiversity loss. However, restoration often remains insufficient to offset …
[HTML][HTML] Cryptic genetic variation: evolution's hidden substrate
AB Paaby, MV Rockman - Nature Reviews Genetics, 2014 - nature.com
Cryptic genetic variation (CGV) is invisible under normal conditions, but it can fuel evolution
when circumstances change. In theory, CGV can represent a massive cache of adaptive …
when circumstances change. In theory, CGV can represent a massive cache of adaptive …
The paradox of intelligence: Heritability and malleability coexist in hidden gene-environment interplay.
Intelligence can have an extremely high heritability, but also be malleable; a paradox that
has been the source of continuous controversy. Here we attempt to clarify the issue, and …
has been the source of continuous controversy. Here we attempt to clarify the issue, and …
[PDF][PDF] Deep learning in population genetics
K Korfmann, OE Gaggiotti… - Genome Biology and …, 2023 - academic.oup.com
Population genetics is transitioning into a data-driven discipline thanks to the availability of
large-scale genomic data and the need to study increasingly complex evolutionary …
large-scale genomic data and the need to study increasingly complex evolutionary …
Hybridization as a facilitator of species range expansion
Explaining the evolution of species geographical ranges is fundamental to understanding
how biodiversity is distributed and maintained. The solution to this classic problem in …
how biodiversity is distributed and maintained. The solution to this classic problem in …
[HTML][HTML] Perspective on the origin, resistance, and spread of the emerging human fungal pathogen Candida auris
Candida auris is a major emerging human fungal pathogen that was first reported in 2009 as
an isolate from the ear canal of a patient in Japan [1]. Since this initial report, C. auris has …
an isolate from the ear canal of a patient in Japan [1]. Since this initial report, C. auris has …
[HTML][HTML] Imiquimod has strain-dependent effects in mice and does not uniquely model human psoriasis
WR Swindell, KA Michaels, AJ Sutter, D Diaconu… - Genome medicine, 2017 - Springer
Background Imiquimod (IMQ) produces a cutaneous phenotype in mice frequently studied
as an acute model of human psoriasis. Whether this phenotype depends on strain or sex …
as an acute model of human psoriasis. Whether this phenotype depends on strain or sex …
Gene Essentiality Analyzed by In Vivo Transposon Mutagenesis and Machine Learning in a Stable Haploid Isolate of Candida albicans
Knowing the full set of essential genes for a given organism provides important information
about ways to promote, and to limit, its growth and survival. For many non-model organisms …
about ways to promote, and to limit, its growth and survival. For many non-model organisms …
Higher-order genetic interactions and their contribution to complex traits
MB Taylor, IM Ehrenreich - Trends in genetics, 2015 - cell.com
The contribution of genetic interactions involving three or more loci to complex traits is poorly
understood. These higher-order genetic interactions (HGIs) are difficult to detect in genetic …
understood. These higher-order genetic interactions (HGIs) are difficult to detect in genetic …