Systemic lupus erythematosus (SLE) is an autoimmune disease mediated by pathogenic
autoantibodies directed against nucleoprotein complexes. Beyond the activation of …

Cerebral malaria (CM) caused by Plasmodium falciparum is a fatal neurological
complication of malaria, resulting in coma and death, and even survivors may suffer long …

The lifestyle of intracellular pathogens, such as malaria parasites, is intimately connected to
that of their host, primarily for nutrient supply. Nutrients act not only as primary sources of …

Leptin, a pleiotropic protein has long been recognized to play an important role in the
regulation of energy homeostasis, metabolism, neuroendocrine function, and other …

With research progress on longevity, we have gradually recognized that cardiac aging
causes changes in heart structure and function, including progressive myocardial …

Malaria, the most prevalent mosquito-borne infectious disease worldwide, has accompanied
humanity for millennia and remains an important public health issue despite advances in its …

Cerebral malaria (CM) is a severe complication of Plasmodium falciparum infection that
results in thousands of deaths each year, mostly in African children. The in vivo mechanisms …

Human performance, endurance, and resilience have biological limits that are genetically
and epigenetically predetermined but perhaps not yet optimized. There are few systematic …

Although the adipose tissue (AT) is a central metabolic organ in the regulation of whole-
body energy homeostasis, it is also an important endocrine and immunological organ. As an …

Undernutrition remains a major issue in global health. Low protein-energy consumption,
results in stunting, wasting and/or underweight, three deleterious forms of malnutrition that …