Cardiac fibrosis is a common pathophysiologic companion of most myocardial diseases,
and is associated with systolic and diastolic dysfunction, arrhythmogenesis, and adverse …

Airway remodeling is generally quite broadly defined as any change in composition,
distribution, thickness, mass or volume and/or number of structural components observed in …

Cardiac fibrosis is characterized by net accumulation of extracellular matrix proteins in the
cardiac interstitium, and contributes to both systolic and diastolic dysfunction in many …

Myocardial infarction is defined as sudden ischemic death of myocardial tissue. In the
clinical context, myocardial infarction is usually due to thrombotic occlusion of a coronary …

Increasing incidences of obesity and diabetes have made diabetic kidney disease (DKD) the
leading cause of chronic kidney disease and end-stage renal disease worldwide. Despite …

Expression of HPV16 early region genes in basal keratinocytes of transgenic mice elicits a
multistage pathway to squamous carcinoma. We report that infiltration by mast cells and …

University of California, San Francisco stimulation. Through these diverse mechanisms,
adhesion, deadhesion, and ECM proteolysis are all brought San Francisco, California …

These days it has been increasingly recognized that mast cells (MCs) are critical
components of host defense against pathogens. In this study, we have provided the first …

Systemic sclerosis (SSc) is a severe auto-immune disease, characterized by vasculopathy
and fibrosis of connective tissues. SSc has a high morbidity and mortality and unfortunately …

Tryptases and chymases are the major proteins stored and secreted by mast cells. The
types, amounts, and properties of these serine peptidases vary by mast cell subtype, tissue …