A remarkable epigenetic remodelling process occurs shortly after fertilization, which restores
totipotency to the zygote. This involves global DNA demethylation, chromatin remodelling …

BACKGROUND Oocyte aging has significant clinical consequences, and yet no treatment
exists to address the age-related decline in oocyte quality. The lack of progress in the …

Prior to zygotic genome activation, early mammalian development relies on maternal-effect
genes to orchestrate the oocyte-to-embryo transition. Recently, a subcortical maternal …

The maintenance of genomic integrity during early embryonic development is important in
order to ensure the proper development of the embryo. Studies from cultured cells have …

Oocyte developmental competence is defined as the capacity of the female gamete to be
fertilized and sustain development to the blastocyst stage. Epigenetic reprogramming, a …

Many functional consequences of mutations on tumor phenotypes in chronic lymphocytic
leukemia (CLL) are unknown. This may be in part due to a scarcity of information on the …

After fertilization, remodeling of the oocyte and sperm genomes is essential to convert these
highly differentiated and transcriptionally quiescent cells into early cleavage‐stage …

The age‐associated decline in female fertility is largely ascribable to a decrease in oocyte
quality. This phenomenon is multifaceted and influenced by numerous interconnected …

Dysfunction of splicing factors often result in abnormal cell differentiation and apoptosis,
especially in neural tissues. Mutations in pre-mRNAs processing factor 31 (PRPF31) cause …

Breast cancer amplified sequence 2 (BCAS2) is involved in multiple biological processes,
including pre-mRNA splicing. However, the physiological roles of BCAS2 are still largely …