Dynamics of the epigenetic landscape during the maternal-to-zygotic transition
MA Eckersley-Maslin, C Alda-Catalinas… - … Reviews Molecular Cell …, 2018 - nature.com
A remarkable epigenetic remodelling process occurs shortly after fertilization, which restores
totipotency to the zygote. This involves global DNA demethylation, chromatin remodelling …
totipotency to the zygote. This involves global DNA demethylation, chromatin remodelling …
BRCA-related ATM-mediated DNA double-strand break repair and ovarian aging
BACKGROUND Oocyte aging has significant clinical consequences, and yet no treatment
exists to address the age-related decline in oocyte quality. The lack of progress in the …
exists to address the age-related decline in oocyte quality. The lack of progress in the …
A maternal functional module in the mammalian oocyte-to-embryo transition
Prior to zygotic genome activation, early mammalian development relies on maternal-effect
genes to orchestrate the oocyte-to-embryo transition. Recently, a subcortical maternal …
genes to orchestrate the oocyte-to-embryo transition. Recently, a subcortical maternal …
[HTML][HTML] Cdk12 is essential for embryonic development and the maintenance of genomic stability
The maintenance of genomic integrity during early embryonic development is important in
order to ensure the proper development of the embryo. Studies from cultured cells have …
order to ensure the proper development of the embryo. Studies from cultured cells have …
Maternal effect factors that contribute to oocytes developmental competence: an update
F Innocenti, G Fiorentino, D Cimadomo… - Journal of assisted …, 2022 - Springer
Oocyte developmental competence is defined as the capacity of the female gamete to be
fertilized and sustain development to the blastocyst stage. Epigenetic reprogramming, a …
fertilized and sustain development to the blastocyst stage. Epigenetic reprogramming, a …
The protein landscape of chronic lymphocytic leukemia
F Meier-Abt, J Lu, E Cannizzaro… - Blood, The Journal …, 2021 - ashpublications.org
Many functional consequences of mutations on tumor phenotypes in chronic lymphocytic
leukemia (CLL) are unknown. This may be in part due to a scarcity of information on the …
leukemia (CLL) are unknown. This may be in part due to a scarcity of information on the …
CHK1‐CDC25A‐CDK1 regulate cell cycle progression and protect genome integrity in early mouse embryos
L Knoblochova, T Duricek, M Vaskovicova… - EMBO …, 2023 - embopress.org
After fertilization, remodeling of the oocyte and sperm genomes is essential to convert these
highly differentiated and transcriptionally quiescent cells into early cleavage‐stage …
highly differentiated and transcriptionally quiescent cells into early cleavage‐stage …
[HTML][HTML] Oocyte aging: looking beyond chromosome segregation errors
The age‐associated decline in female fertility is largely ascribable to a decrease in oocyte
quality. This phenomenon is multifaceted and influenced by numerous interconnected …
quality. This phenomenon is multifaceted and influenced by numerous interconnected …
Prpf31 is essential for the survival and differentiation of retinal progenitor cells by modulating alternative splicing
J Li, F Liu, Y Lv, K Sun, Y Zhao, J Reilly… - Nucleic acids …, 2021 - academic.oup.com
Dysfunction of splicing factors often result in abnormal cell differentiation and apoptosis,
especially in neural tissues. Mutations in pre-mRNAs processing factor 31 (PRPF31) cause …
especially in neural tissues. Mutations in pre-mRNAs processing factor 31 (PRPF31) cause …
[HTML][HTML] BCAS2 is involved in alternative mRNA splicing in spermatogonia and the transition to meiosis
Breast cancer amplified sequence 2 (BCAS2) is involved in multiple biological processes,
including pre-mRNA splicing. However, the physiological roles of BCAS2 are still largely …
including pre-mRNA splicing. However, the physiological roles of BCAS2 are still largely …