Metabolome analysis is a key component of serum/plasma metabolomics studies for clinical
and biological applications. There are several steps involved, including pre-analytical …

As links between genotype and phenotype, small-molecule metabolites are attractive
biomarkers for disease diagnosis, prognosis, classification, drug screening and treatment …

Sphingolipids are important for the physicochemical properties of cellular membranes and
deregulated in tumors. In human colon cancer tissue ceramide synthase (CerS) 4 and …

Endocannabinoids (ECs), such as anandamide and 2-arachidonyl glycerol (2-AG),
contribute to the pathology of inflammatory, malignant, cardiovascular, metabolic and mental …

Short-chain fatty acids (SCFAs), the end products of gut microbial fermentation of dietary
fibers and non-digestible polysaccharides, act as a link between the microbiome, immune …

Background Chemotherapy-induced neuropathic pain (CIPN) describes a pathological pain
state that occurs dose-dependently as a side effect and can limit or even impede an effective …

Discrepant sample processing remains a significant challenge within blood metabolomics
research, introducing non-biological variation into the measured metabolome and biasing …

Abstract Background and Purpose Non‐steroidal anti‐inflammatory drugs (NSAIDs) are the
most widely prescribed drugs in the world due to their analgesic, antipyretic and anti …

Lipids are biomolecules involved in numerous (patho-) physiological processes and their
elucidation in tissue samples is of particular interest. However, tissue analysis goes hand in …

Non-alcoholic steatohepatitis (NASH) and alcoholic steatohepatitis (ASH) are the leading
causes of liver disease worldwide. To identify disease-specific pathomechanisms, we …