Psoriasis is an incurable skin disease that develops in about two-thirds of patients before the
age of 40 and requires lifelong treatment; its pathological mechanisms have not been fully …

Breast cancer is characterized by the uncontrolled proliferation of breast cells, with a high
incidence reported in 2020 to have affected over 2 million women. In recent years, the …

Tumor biomarkers, the substances which are produced by tumors or the body's responses to
tumors during tumorigenesis and progression, have been demonstrated to possess critical …

Targeted protein degradation (TPD) represents a revolutionary therapeutic strategy in
disease management, providing a stark contrast to traditional therapeutic approaches like …

Breast cancer became the most diagnosed cancer in the world in 2020. Chemotherapy is
still the leading clinical strategy in breast cancer treatment, followed by hormone therapy …

Pyridazine, as a privileged scaffold, has been extensively utilized in drug development due
to its multiple biological activities. Especially around its distinctive anticancer property, a …

Immune checkpoint inhibitors (ICI) have achieved unprecedented clinical success in cancer
treatment. However, drug resistance to ICI therapy is a major hurdle that prevents cancer …

Cyclin-dependent kinases (CDKs) regulate cell division at multiple levels. Aberrant
proliferation induced by abnormal cell cycle is a hallmark of cancer. Over the past few …

The E2F transcription factor family, whose members are encoded by the E2F1-E2F8 genes,
plays pivotal roles in the cell cycle, apoptosis, metabolism, stemness, metastasis, aging …

Metastasis remains the principal cause of cancer-related lethality despite advancements in
cancer treatment. Dysfunctional epigenetic alterations are crucial in the metastatic cascade …