[HTML][HTML] Human organoids in basic research and clinical applications
Organoids are three-dimensional (3D) miniature structures cultured in vitro produced from
either human pluripotent stem cells (hPSCs) or adult stem cells (AdSCs) derived from …
either human pluripotent stem cells (hPSCs) or adult stem cells (AdSCs) derived from …
Organs-on-chips: into the next decade
LA Low, C Mummery, BR Berridge, CP Austin… - Nature Reviews Drug …, 2021 - nature.com
Abstract Organs-on-chips (OoCs), also known as microphysiological systems or 'tissue
chips'(the terms are synonymous), have attracted substantial interest in recent years owing …
chips'(the terms are synonymous), have attracted substantial interest in recent years owing …
Establishment of patient-derived cancer organoids for drug-screening applications
E Driehuis, K Kretzschmar, H Clevers - Nature protocols, 2020 - nature.com
Adult stem cell–based organoid technology is a versatile tool for the generation and long-
term maintenance of near-native 3D epithelial tissues in vitro. The generation of cancer …
term maintenance of near-native 3D epithelial tissues in vitro. The generation of cancer …
[HTML][HTML] Organ-on-a-chip: Recent breakthroughs and future prospects
Q Wu, J Liu, X Wang, L Feng, J Wu, X Zhu… - Biomedical engineering …, 2020 - Springer
The organ-on-a-chip (OOAC) is in the list of top 10 emerging technologies and refers to a
physiological organ biomimetic system built on a microfluidic chip. Through a combination of …
physiological organ biomimetic system built on a microfluidic chip. Through a combination of …
[HTML][HTML] Wilms tumour
F Spreafico, CV Fernandez, J Brok, K Nakata… - Nature Reviews …, 2021 - nature.com
Wilms tumour (WT) is a childhood embryonal tumour that is paradigmatic of the intersection
between disrupted organogenesis and tumorigenesis. Many WT genes play a critical (non …
between disrupted organogenesis and tumorigenesis. Many WT genes play a critical (non …
Cancer modeling meets human organoid technology
Organoids are microscopic self-organizing, three-dimensional structures that are grown from
stem cells in vitro. They recapitulate many structural and functional aspects of their in vivo …
stem cells in vitro. They recapitulate many structural and functional aspects of their in vivo …
A brief history of organoids
C Corrò, L Novellasdemunt… - American Journal of …, 2020 - journals.physiology.org
In vitro cell cultures are crucial research tools for modeling human development and
diseases. Although the conventional monolayer cell cultures have been widely used in the …
diseases. Although the conventional monolayer cell cultures have been widely used in the …
Human organoids: tools for understanding biology and treating diseases
F Schutgens, H Clevers - Annual Review of Pathology …, 2020 - annualreviews.org
Organoids are in vitro–cultured three-dimensional structures that recapitulate key aspects of
in vivo organs. They can be established from pluripotent stem cells and from adult stem …
in vivo organs. They can be established from pluripotent stem cells and from adult stem …
Strategies for 3D bioprinting of spheroids: A comprehensive review
Biofabricated tissues have found numerous applications in tissue engineering and
regenerative medicine in addition to the promotion of disease modeling and drug …
regenerative medicine in addition to the promotion of disease modeling and drug …
Xenograft and organoid model systems in cancer research
Patient‐derived tumour xenografts and tumour organoids have become important preclinical
model systems for cancer research. Both models maintain key features from their parental …
model systems for cancer research. Both models maintain key features from their parental …