Recent advances in the knowledge of the mechanisms of leptin physiology and actions in neurological and metabolic pathologies
ME Casado, R Collado-Pérez, LM Frago… - International Journal of …, 2023 - mdpi.com
Excess body weight is frequently associated with low-grade inflammation. Evidence
indicates a relationship between obesity and cancer, as well as with other diseases, such as …
indicates a relationship between obesity and cancer, as well as with other diseases, such as …
Adipose tissue hyperplasia and hypertrophy in common and syndromic obesity—The case of BBS obesity
A Horwitz, R Birk - Nutrients, 2023 - mdpi.com
Obesity is a metabolic state generated by the expansion of adipose tissue. Adipose tissue
expansion depends on the interplay between hyperplasia and hypertrophy, and is mainly …
expansion depends on the interplay between hyperplasia and hypertrophy, and is mainly …
MC-LR aggravates liver lipid metabolism disorders in obese mice fed a high-fat diet via PI3K/AKT/mTOR/SREBP1 signaling pathway
H Chu, C Du, Y Yang, X Feng, L Zhu, J Chen, F Yang - Toxins, 2022 - mdpi.com
Obesity, a metabolic disease caused by excessive fat accumulation in the body, has
attracted worldwide attention. Microcystin-LR (MC-LR) is a hepatotoxic cyanotoxin which …
attracted worldwide attention. Microcystin-LR (MC-LR) is a hepatotoxic cyanotoxin which …
The Regulatory Role of MicroRNAs in Obesity and Obesity-Derived Ailments
JA Benavides-Aguilar, A Torres-Copado… - Genes, 2023 - mdpi.com
Obesity is a condition that is characterized by the presence of excessive adipose tissue in
the body. Obesity has become one of the main health concerns worldwide since it can lead …
the body. Obesity has become one of the main health concerns worldwide since it can lead …
The effects of subcutaneous Tirzepatide on obesity and overweight: a systematic review and meta‐regression analysis of randomized controlled trials
Background Despite the fact that obesity and overweight are serious major health problems
worldwide, fighting against them is also considered a challenging issue. Several …
worldwide, fighting against them is also considered a challenging issue. Several …
Melanocortin 4 receptor (MC4R) gene variants in children and adolescents having familial early-onset obesity: genetic and clinical characteristics
Melanocortin 4 receptor gene plays an important role in food intake, energy balance, and
weight control. The autosomal dominantly inherited MC4R variants cause obesity by …
weight control. The autosomal dominantly inherited MC4R variants cause obesity by …
Correlates of food addiction and eating behaviours in patients with morbid obesity
P Schankweiler, D Raddatz, T Ellrott, C Hauck Cirkel - Obesity Facts, 2023 - karger.com
Introduction: Food addiction (FA) is a promising construct regarding the multifactorial
aetiology of obesity and the search for therapeutic approaches. However, there is an …
aetiology of obesity and the search for therapeutic approaches. However, there is an …
Role of the FKBP5 polymorphism rs1360780, age, sex, and type of surgery in weight loss after bariatric surgery: a follow-up study
Background Emerging evidence suggests that the FK506 binding protein 51
(FKBP5/FKBP51), encoded by the FKBP5 gene, influences weight and metabolic regulation …
(FKBP5/FKBP51), encoded by the FKBP5 gene, influences weight and metabolic regulation …
Association of physical activity with increased PI3K and Akt mRNA levels in adipose tissues of obese and non-obese adults
Abstract Phosphatidylinositol-3-kinase (PI3K)/Akt signaling pathway regulates glucose and
lipid metabolism. We examined the association of PI3K and Akt expression in visceral (VAT) …
lipid metabolism. We examined the association of PI3K and Akt expression in visceral (VAT) …
Identification of genetic variants in 65 obesity related genes in a cohort of Portuguese obese individuals
C Ginete, B Serrasqueiro, J Silva-Nunes, L Veiga… - Genes, 2021 - mdpi.com
Obesity is a major public health problem, which has a strong genetic component that
interplays with environmental factors. Several genes are known to be implicated in the …
interplays with environmental factors. Several genes are known to be implicated in the …