Camptothecin resistance in cancer: insights into the molecular mechanisms of a DNA-damaging drug
GL Beretta, L Gatti, P Perego… - Current medicinal …, 2013 - ingentaconnect.com
Poisoning of DNA topoisomerase I is the mechanism by which camptothecins interfere with
tumor growth. Although the clinical use of camptothecins has had a significant impact on …
tumor growth. Although the clinical use of camptothecins has had a significant impact on …
Mechanisms of apoptosis by the tumor suppressor Par‐4
Par‐4 is a pro‐apoptotic, tumor suppressor protein that induces apoptosis selectively in
cancer cells. Endoplasmic reticulum‐stress and higher levels of protein kinase A in tumor …
cancer cells. Endoplasmic reticulum‐stress and higher levels of protein kinase A in tumor …
The tumor suppressor Par-4 activates an extrinsic pathway for apoptosis
R Burikhanov, Y Zhao, A Goswami, S Qiu… - Cell, 2009 - cell.com
Summary Prostate apoptosis response-4 (Par-4) is a proapoptotic protein with intracellular
functions in the cytoplasm and nucleus. Unexpectedly, we noted Par-4 protein is …
functions in the cytoplasm and nucleus. Unexpectedly, we noted Par-4 protein is …
RNA interacts with topoisomerase I to adjust DNA topology
M Bhola, K Abe, P Orozco, H Rahnamoun… - Molecular cell, 2024 - cell.com
Topoisomerase I (TOP1) is an essential enzyme that relaxes DNA to prevent and dissipate
torsional stress during transcription. However, the mechanisms underlying the regulation of …
torsional stress during transcription. However, the mechanisms underlying the regulation of …
Accelerated cardiomyocyte senescence contributes to late-onset doxorubicin-induced cardiotoxicity
MA Mitry, D Laurent, BL Keith, E Sira… - … of Physiology-Cell …, 2020 - journals.physiology.org
Children surviving cancer and chemotherapy are at risk for adverse health events including
heart failure that may be delayed by years. Although the early effects of doxorubicin-induced …
heart failure that may be delayed by years. Although the early effects of doxorubicin-induced …
Arylquins target vimentin to trigger Par-4 secretion for tumor cell apoptosis
The tumor suppressor protein prostate apoptosis response-4 (Par-4), which is secreted by
normal cells, selectively induces apoptosis in cancer cells. We identified a 3-arylquinoline …
normal cells, selectively induces apoptosis in cancer cells. We identified a 3-arylquinoline …
Prostate apoptosis response-4 and tumor suppression: It's not just about apoptosis anymore
AR Cheratta, F Thayyullathil, S Pallichankandy… - Cell Death & …, 2021 - nature.com
The tumor suppressor prostate apoptosis response-4 (Par-4) has recently turned 'twenty-
five'. Beyond its indisputable role as an apoptosis inducer, an increasing and sometimes …
five'. Beyond its indisputable role as an apoptosis inducer, an increasing and sometimes …
Inhibition of Twist1-mediated invasion by Chk2 promotes premature senescence in p53-defective cancer cells
Twist1, a basic helix–loop–helix transcription factor is implicated as a key mediator of
epithelial–mesenchymal transition (EMT) and metastatic dissemination in p53-deficient …
epithelial–mesenchymal transition (EMT) and metastatic dissemination in p53-deficient …
Prostate apoptosis response protein 4 sensitizes human colon cancer cells to chemotherapeutic 5-FU through mediation of an NFκB and microRNA network
Background Diminished expression or activity of prostate apoptosis response protein 4 (Par-
4) has been demonstrated in a number of cancers, although reports on Par-4 expression …
4) has been demonstrated in a number of cancers, although reports on Par-4 expression …
4′-Demethyl-deoxypodophyllotoxin glucoside isolated from Podophyllum hexandrum exhibits potential anticancer activities by altering Chk-2 signaling pathway in …
We investigated the root of Podophyllum hexandrum as a potential source of lead bioactive
metabolites with anticancer activity. The present study led to the isolation of six known …
metabolites with anticancer activity. The present study led to the isolation of six known …