Reactive carbonyls are widespread species in living organisms and mainly known for their
damaging effects. The most abundant reactive carbonyl species (RCS) are derived from …

Alzheimer's disease is the most common and lethal neurodegenerative disorder. The major
hallmarks of Alzheimer's disease are extracellular aggregation of amyloid β peptides and …

Modern diets can cause modern diseases. Research has linked a metabolite of sugar,
methylglyoxal (MG), to the development of diabetic complications, but the exact mechanism …

The dipeptide carnosine has been observed to exert antiaging activity at cellular and whole
animal levels. This review discusses the possible mechanisms by which carnosine may …

Aging is a multifactorial process that involves changes at the cellular, tissue, organ and the
whole body levels resulting in decreased functioning, development of diseases, and …

Methylglyoxal (MG) is a highly reactive compound derived mainly from glucose and fructose
metabolism. This metabolite has been implicated in diabetic complications as it is a strong …

Astrocytes become activated in Alzheimer's disease (AD), contributing to and reinforcing an
inflammatory cascade. It is proposed that by transforming from a basal to a reactive state …

OBJECTIVE The incidence of high dietary carbohydrate-induced type 2 diabetes is
increasing worldwide. Methylglyoxal (MG) is a reactive glucose metabolite and a major …

Glucose and fructose metabolism originates the highly reactive byproduct methylglyoxal
(MG), which is a strong precursor of advanced glycation end products (AGE). The MG has …

The effects of methylglyoxal (MG) on mitochondria with specific foci on peroxynitrite
(ONOO−) production, manganese superoxide dismutase (MnSOD) activity, and …