Kynurenines in the CNS: recent advances and new questions
Various pathologies of the central nervous system (CNS) are accompanied by alterations in
tryptophan metabolism. The main metabolic route of tryptophan degradation is the …
tryptophan metabolism. The main metabolic route of tryptophan degradation is the …
[HTML][HTML] Kynurenines in CNS disease: regulation by inflammatory cytokines
BM Campbell, E Charych, AW Lee… - Frontiers in neuroscience, 2014 - frontiersin.org
The kynurenine pathway (KP) metabolizes the essential amino acid tryptophan and
generates a number of neuroactive metabolites collectively called the kynurenines …
generates a number of neuroactive metabolites collectively called the kynurenines …
[HTML][HTML] Kynurenine pathway metabolomics predicts and provides mechanistic insight into multiple sclerosis progression
Activation of the kynurenine pathway (KP) of tryptophan metabolism results from chronic
inflammation and is known to exacerbate progression of neurodegenerative disease. To …
inflammation and is known to exacerbate progression of neurodegenerative disease. To …
The kynurenine pathway in schizophrenia and bipolar disorder
The kynurenine pathway of tryptophan degradation generates several neuroactive
compounds. Of those, kynurenic acid is an N-methyl-d-aspartate (NMDA) and alpha7 …
compounds. Of those, kynurenic acid is an N-methyl-d-aspartate (NMDA) and alpha7 …
A dialogue between the immune system and brain, spoken in the language of serotonin
NL Baganz, RD Blakely - ACS chemical neuroscience, 2013 - ACS Publications
Neuropsychiatric disorders have long been linked to both immune system activation and
alterations in serotonin (5-HT) signaling. In the CNS, the contributions of 5-HT modulate a …
alterations in serotonin (5-HT) signaling. In the CNS, the contributions of 5-HT modulate a …
Cytokine–serotonin interaction through IDO: a neurodegeneration hypothesis of depression
AM Myint, YK Kim - Medical hypotheses, 2003 - Elsevier
There are different theories and hypotheses related to the aetiology of depression. The
interaction between brain 5-HT level and the activity of its autoreceptors plays a role in mood …
interaction between brain 5-HT level and the activity of its autoreceptors plays a role in mood …
Cytokine imbalance in the pathophysiology of major depressive disorder
OBJECTIVE: A substantial body of evidence indicates that dysregulation of the immune
system is associated with Major Depressive Disorder (MDD). Because most cytokines have …
system is associated with Major Depressive Disorder (MDD). Because most cytokines have …
The role of indoleamine 2, 3-dioxygenase (IDO) in the pathophysiology of interferon-α-induced depression
MC Wichers, M Maes - Journal of Psychiatry and Neuroscience, 2004 - jpn.ca
The mechanisms by which administration of interferon-α induces neuropsychiatric side
effects, such as depressive symptoms and changes in cognitive function, are not clear as …
effects, such as depressive symptoms and changes in cognitive function, are not clear as …
[HTML][HTML] Current evidence for a role of the kynurenine pathway of tryptophan metabolism in multiple sclerosis
MD Lovelace, B Varney, G Sundaram… - Frontiers in …, 2016 - frontiersin.org
The kynurenine pathway (KP) is the major metabolic pathway of the essential amino acid
tryptophan (TRP). Stimulation by inflammatory molecules, such as interferon-γ (IFN-γ), is the …
tryptophan (TRP). Stimulation by inflammatory molecules, such as interferon-γ (IFN-γ), is the …
A review of the bioactivity of coffee, caffeine and key coffee constituents on inflammatory responses linked to depression
Coffee is a widely consumed beverage containing numerous biologically active constituents
predominantly belonging to the polyphenol and alkaloid classes. It has been established …
predominantly belonging to the polyphenol and alkaloid classes. It has been established …