Ovarian cancer is a gynecological cancer with high mortality and a heterogeneous nature
which complicates its early detection and primary prevention. Numerous studies have …

Glucocorticoids have been used in clinical oncology for over half a century. The clinical
applications of glucocorticoids in oncology are mainly dependent on their pro-apoptotic …

Background Ovarian cancer has the highest mortality among gynecological cancers due to
late diagnosis and lack of effective targeted therapy. Although the study of interplay between …

Ras oncoproteins play pivotal roles in both the development and maintenance of many
tumor types. Unfortunately, these proteins are difficult to directly target using traditional …

The early onset breast cancer patients (age≤ 40) often display higher incidence of axillary
lymph node metastasis, and poorer five-year survival than the late-onset patients. To identify …

Deletion of the long arm of chromosome 11 (11q deletion) is one of the most frequent events
that occur during the development of aggressive neuroblastoma. Clinically, 11q deletion is …

Glioma, also known as glioblastoma multiforme (GBM), is the most prevalent and most lethal
primary brain tumor in adults. Gliomas are highly invasive tumors with the highest death rate …

Critical features of stem cells include anchoring within a niche and activation upon injury.
Notch signaling maintains skeletal muscle satellite (stem) cell quiescence by inhibiting …

Thanks to their anti-inflammatory, anti-oedema, and anti-allergy properties, glucocorticoids
are among the most widely prescribed drugs in patients with cancer. The indications for …

Metastasis is known as the most life-threatening event in cancer patients. In principle, the
immune system can prevent tumor development. However, dysfunctional T cells may fail to …