Synthesis of chalcones derivatives and their biological activities: a review

NAA Elkanzi, H Hrichi, RA Alolayan, W Derafa… - ACS …, 2022 - ACS Publications
Chalcone derivatives are considered valuable species because they possess a
ketoethylenic moiety, CO–CH═ CH–. Due to the presence of a reactive α, β-unsaturated …

[HTML][HTML] Perspectives on the Role of Isoliquiritigenin in Cancer

KL Wang, YC Yu, SM Hsia - Cancers, 2021 - mdpi.com
Simple Summary Isoliquiritigenin (ISL), a natural bioactive compound with a chalcone
structure, demonstrates high antitumor efficacy. This review presents a summary of the latest …

The biological activities, molecular docking studies, and anticancer effects of 1-arylsuphonylpyrazole derivatives

P Taslimi, Y Erden, S Mamedov… - Journal of …, 2021 - Taylor & Francis
This work is devoted to definition of the direction of reaction between 1-
benzenesulfonylimino pyridinium chloride and α-or β-halo-containing sulfamides …

Design of novel quinoline derivatives as antibreast cancer using 3D-QSAR, molecular docking and pharmacokinetic investigation

S El Rhabori, A El Aissouq, S Chtita, F Khalil - Anti-Cancer Drugs, 2022 - journals.lww.com
Breast cancer has been one of the most challenging women's cancers and leading cause of
mortality for decades. There are several studies being conducted all the time to find a cure …

Aromatase inhibitors for the treatment of breast cancer: An overview (2019–2023)

N Bhatia, S Thareja - Bioorganic Chemistry, 2024 - Elsevier
Aromatase inhibition is considered a legitimate approach for the treatment of ER-positive
(ER+) breast cancer as it accounts for more than 70% of breast cancer cases. Aromatase …

Role of natural and synthetic flavonoids as potential aromatase inhibitors in breast cancer: structure-activity relationship perspective

U Shah, A Patel, S Patel, M Patel… - Anti-Cancer Agents …, 2022 - ingentaconnect.com
World Health Organization categorized breast cancer as one of the leading cancer types in
females worldwide, and its treatment remains challenging. Accumulated evidence …

[HTML][HTML] In silico drug evaluation and drug research of bioactive molecule methyl 4-bromo-2-fluorobenzoate

M Julie, T Prabhu, FB Asif, S Muthu - Journal of Faculty of Pharmacy …, 2021 - dergipark.org.tr
Objective: The biochemical analysis plays an important role in pharmaceutical chemistry.
Fungal infections are the most common infectious disease worldwide. The result of this …

In Vitro Cytotoxicity and Aromatase Inhibitory Activity of Flavonoids: Synthesis, Molecular Docking and In Silico ADME Prediction

U Shah, S Patel, M Patel, N Jain… - Anti-Cancer Agents …, 2022 - ingentaconnect.com
Background: Many natural and synthetic flavonoids have been studied and documented by
inhibiting aromatase enzymes for their anti-cancer activity against breast carcinoma. The …

Molecular modeling and ADMET predictions of flavonoids as prospective aromatase inhibitors

K Gandhi, U Shah, S Patel, M Patel, S Patel… - Indian Journal of …, 2022 - op.niscpr.res.in
With the advent of a myriad of treatment possibilities for breast cancer, enzyme inhibition
turns out to be the prevailing strategy for inhibiting estrogen biosynthesis. Aromatization of …

Apoptosis mediated cytotoxic potential of Erythrina variegata L. stem bark in human breast carcinoma cell lines

R John, BJ Kariyil, U PTA - 2021 - nopr.niscpr.res.in
Erythrina variegata L.(Fam. Fabaceae) is traditionally known for antitumour, expectorant,
febrifuge, antibacterial and antioxidant activities. In the present study, we did cytotoxic …