Drug resistance has compromised the efficacy of chemotherapy. The dysregulation of drug
transporters including P-glycoprotein (P-gp) can mediate drug resistance through drug …

In recent years, there has been an increased understanding of P-glycoprotein (P-GP)-
mediated pharmacokinetic interactions. In addition, its role in modifying the bioavailability of …

We have characterized the normal human tissue distribution and tumor expression of the
human multidrug resistance gene (MDR1) product P-glycoprotein (Pgp) by …

Homologous recombination-based gene targeting using Mus musculus embryonic stem
cells has greatly impacted biomedical research. This study presents a powerful new …

Background Increased levels of P-glycoprotein occur in some osteosarcomas. In this study
we determined the relation between P-glycoprotein status and outcome in patients with high …

The gene responsible for multidrug resistance (mdr), which encodes the P-glycoprotein, is a
member of a multigene family. We have identified distinct mdr gene transcripts encoded by …

Possible correlation between the effects of electromagnetic fields (EFs) on voltage-gated
Ca2+ channels, cell proliferation and apoptosis was investigated in neural and …

Tumour cell resistance to cytotoxic drugs is considered to be one of the major causes of
failure of clinical chemotherapy. Experimental models of drug-resistant tumours have been …

The B-cell neoplasms, multiple myeloma and non-Hodgkin's lymphoma, frequently become
drug resistant, despite initial responses to chemotherapeutic drugs. Tumor cells from eight …

The development of multidrug resistance in MCF-7 human breast cancer cells and the
acquisition of broad resistance to xenobiotics in rat hyperplastic nodules are both associated …