Chagas disease (CD) is a parasitic, systemic, chronic, and often fatal illness caused by
infection with the protozoan Trypanosoma cruzi. The World Health Organization classifies …

Chagas disease is the most important protozoan infection in the Americas, and constitutes a
significant public health concern throughout the world. Development of new medications …

Chagas disease is a tropical infection caused by the protozoan parasite Trypanosoma cruzi
and a global public health concern. It is a paradigmatic example of a chronic disease without …

Abstract Background The Target Product Profile (TPP) is a tool used in industry to guide
development strategies by addressing user needs and fostering effective communication …

From a systematic review framework, we analysed the clinical evidence on the effectiveness
and safety of monotherapy and combination chemotherapy for Chagas disease (ChD) …

Introduction Carbonic anhydrase (CA) arose significant interest as a potential new target for
Chagas disease since its discovery in Trypanosoma cruzi in 2013. Benznidazole and …

The α-gal epitope, which refers to the carbohydrate α-d-Gal p-(1→ 3)-β-d-Gal p-(1→ 4)-d-
GlcNAc-R, was first described in the glycoconjugates of mammals other than humans …

Chagas disease is a neglected tropical disease caused by the protozoan parasite
Trypanosoma cruzi that endangers almost 70 million people worldwide. The only two drugs …

Leishmaniasis and Chagas are among the most significant neglected tropical diseases. Due
to several drawbacks with the current chemotherapy, developing new antikinetoplastid …

Chagas disease is usually caused by tropical infection with the insect-transmitted protozoan
Trypanosoma cruzi. Currently, Chagas disease is a major public health concern worldwide …