Amorphous solid dispersion (ASD) is one of the most effective approaches for delivering
poorly soluble drugs. In ASDs, polymeric materials serve as the carriers in which the drugs …

Twenty-five years ago, Hancock and Parks asked a provocative question:“what is the true
solubility advantage for amorphous pharmaceuticals?” Difficulties in determining the …

Does the performance of an amorphous solid dispersion rely on having 100% amorphous
content? What specifications are appropriate for crystalline content within an amorphous …

The particle drifting effect, where nanosized colloidal drug particles overcome the diffusional
resistance of the aqueous boundary layer adjacent to the intestinal wall and increase drug …

This study aimed to investigate the impact of amorphous solubility and colloidal drug-rich
droplets on drug absorption. The amorphous solubility of cilnidipine (CND) in AS-HF grade …

Biorelevant dissolution testing has been widely used to better understand a drug or
formulation's behavior in the human gastrointestinal (GI) tract. The successful evaluation of …

Amorphous solid dispersion (ASD) has been widely used to enhance the oral bioavailability
of water-insoluble drugs for oral delivery because of its advantages of enhancing solubility …

The purpose of this study was twofold: to identify the growth mechanisms of amorphous
nanoparticles in solution and during the drying process at high temperatures, and to guide …

The use of amorphous solid dispersions (ASDs) in commercial drug products has increased
in recent years due to the large number of poorly soluble drugs in the pharmaceutical …

Highlights•Acceptor compartment media compositions used in ex vivo permeability studies
for poorly soluble drugs are critically evaluated.•An algorithm for selecting suitable solubility …