The ever‐growing global threats to human life caused by the human acute respiratory virus
(RV) infections have cost billions of lives, created a significant economic burden, and …

Nearly all infectious agents contain DNA or RNA genomes, making sequencing an attractive
approach for pathogen detection. The cost of high-throughput or next-generation …

Background Metagenomic next-generation sequencing (mNGS) was suggested to
potentially replace traditional microbiological methodology because of its …

Agnostic metagenomic next-generation sequencing (mNGS) has emerged as a promising
single, universal pathogen detection method for infectious disease diagnostics. This …

The rapid development of next-generation sequencing (NGS) technology, including
advances in sequencing chemistry, sequencing technologies, bioinformatics, and data …

Current molecular diagnostics of human pathogens provide limited information that is often
not sufficient for outbreak and transmission investigation. Next generation sequencing …

Metagenomic next-generation sequencing (mNGS) is increasingly being applied in clinical
laboratories for unbiased culture-independent diagnosis. Whether it can be a next routine …

Lower respiratory tract infections (LRTIs) lead to more deaths each year than any other
infectious disease category. Despite this, etiologic LRTI pathogens are infrequently …

Background Metagenomic next-generation sequencing (mNGS) has changed the diagnosis
landscape of lower respiratory tract infections (LRIs). With the development of newer …

Context.—Metagenomic sequencing can be used for detection of any pathogens using
unbiased, shotgun next-generation sequencing (NGS), without the need for sequence …