Tetrazole derivatives are a prime class of heterocycles, very important to medicinal
chemistry and drug design due to not only their bioisosterism to carboxylic acid and amide …

Metalated isocyanides are highly versatile organometallics. Central to the reactivity of
metalated isocyanides is the presence of two orthogonally reactive carbons, a highly …

Despite the diversity of reactions catalyzed by 2-oxoglutarate-dependent nonheme iron
(Fe/2OG) enzymes identified in recent years, only a limited number of these enzymes have …

We describe here the synthesis of libraries of novel 1-subtituted-5-aryl-1H-imidazole, 5-aryl-
4-tosyl-4, 5-dihydro-1, 3-oxazole and 5-aryl-1, 3-oxazole fragments via microwave (MW) …

Diarylmethanamines as a structural motif are frequently encountered in bioactive molecules,
drugs, pharmaceutical candidates, and ligands. However, the existing synthetic methods …

Azirine-containing dipeptides and depsipeptides with a wide range of substituents have
been synthesized in high yields via the Passerini and Ugi multicomponent reactions (MCRs) …

A new electrochemical method for the preparation of isocyanides from easily accessible
aminotetrazole derivatives has been developed, which tolerates an unprecedented range of …

Oxazoles are rapidly assembled through a sequential deprotonation–condensation of
Asmic, anisylsulfanylmethylisocyanide, with esters followed by sulfanyl–lithium exchange …

Multicomponent (MCRs) reactions are classified as one-pot reaction where more than two
starting materials are employed to form a single product that contains the building blocks of …

A dearomatization-dislocation-coupling cascade rapidly transforms aromatic isocyanides
into highly functionalized cyclohexadienes. The facile cascade installs an exceptional …