[HTML][HTML] Targeted therapy for head and neck cancer: signaling pathways and clinical studies
Head and neck cancer (HNC) is malignant, genetically complex and difficult to treat and is
the sixth most frequent cancer, with tobacco, alcohol and human papillomavirus being major …
the sixth most frequent cancer, with tobacco, alcohol and human papillomavirus being major …
[HTML][HTML] Wnt/β-catenin signaling plays an ever-expanding role in stem cell self-renewal, tumorigenesis and cancer chemoresistance
Wnt signaling transduces evolutionarily conserved pathways which play important roles in
initiating and regulating a diverse range of cellular activities, including cell proliferation …
initiating and regulating a diverse range of cellular activities, including cell proliferation …
Wnt signaling controls the fate of mesenchymal stem cells
L Ling, V Nurcombe, SM Cool - Gene, 2009 - Elsevier
Multipotential mesenchymal stem cells (MSCs) are able to differentiate along several known
lineages and have been shown to be efficacious for in vivo wound repair. The growth and …
lineages and have been shown to be efficacious for in vivo wound repair. The growth and …
[HTML][HTML] Advances in targeted therapy mainly based on signal pathways for nasopharyngeal carcinoma
Y Kang, W He, C Ren, J Qiao, Q Guo, J Hu… - Signal transduction and …, 2020 - nature.com
Nasopharyngeal carcinoma (NPC) is a malignant epithelial carcinoma of the head and neck
region which mainly distributes in southern China and Southeast Asia and has a crucial …
region which mainly distributes in southern China and Southeast Asia and has a crucial …
HOTAIR, a prognostic factor in esophageal squamous cell carcinoma, inhibits WIF‐1 expression and activates W nt pathway
XS Ge, HJ Ma, XH Zheng, HL Ruan, XY Liao… - Cancer …, 2013 - Wiley Online Library
Long non‐coding RNA s (L nc RNA s) have been recently found to be pervasively
transcribed in the genome and critical regulators of the epigenome. HOTAIR, as a well …
transcribed in the genome and critical regulators of the epigenome. HOTAIR, as a well …
Nasopharyngeal carcinoma: molecular pathogenesis and therapeutic developments
Nasopharyngeal carcinoma (NPC) is a prevalent tumour in southern China and southeast
Asia, particularly in the Cantonese population, where its incidence has remained high for …
Asia, particularly in the Cantonese population, where its incidence has remained high for …
Deciphering the molecular genetic basis of NPC through molecular, cytogenetic, and epigenetic approaches
Nasopharyngeal carcinoma (NPC) is consistently associated with EBV infection and
prevalence in southern China and Southeast Asia. In addition to EBV, the development of …
prevalence in southern China and Southeast Asia. In addition to EBV, the development of …
Nasopharyngeal cancer: molecular landscape
Nasopharyngeal carcinoma (NPC) is a unique epithelial malignancy arising from the
superior aspect of the pharyngeal mucosal space, associated with latent Epstein-Barr virus …
superior aspect of the pharyngeal mucosal space, associated with latent Epstein-Barr virus …
[HTML][HTML] USP15 negatively regulates lung cancer progression through the TRAF6-BECN1 signaling axis for autophagy induction
MJ Kim, Y Min, SK Jeong, J Son, JY Kim, JS Lee… - Cell death & …, 2022 - nature.com
TNF receptor-associated factor 6 (TRAF6)-BECN1 signaling axis plays a pivotal role in
autophagy induction through ubiquitination of BECN1, thereby inducing lung cancer …
autophagy induction through ubiquitination of BECN1, thereby inducing lung cancer …
Refining the role for adult stem cells as cancer cells of origin
AC White, WE Lowry - Trends in cell biology, 2015 - cell.com
Significant progress has been made to identify the cells at the foundation of tumorigenesis,
the cancer cell of origin (CCO). The majority of data points towards resident adult stem cells …
the cancer cell of origin (CCO). The majority of data points towards resident adult stem cells …