The proteins encoded by the two major breast cancer susceptibility genes, BRCA1 and
BRCA2, work in a common pathway of genome protection. However, the two proteins work …

Germline mutations in the BRCA1, BRCA2 and Fanconi anaemia genes confer cancer
susceptibility, and the proteins encoded by these genes have distinct functions in related …

ContextGene expression analysis has identified several breast cancer subtypes, including
basal-like, human epidermal growth factor receptor-2 positive/estrogen receptor negative …

This 2004 volume in the World Health Organization series on histologic and genetic typing
of human tumors covers tumors of the kidney, urinary system, prostate, testis and …

Triple-negative breast cancer (TNBC) is defined by a lack of expression of both estrogen
and progesterone receptor as well as human epidermal growth factor receptor 2. It is …

Background Although numerous mouse models of breast carcinomas have been developed,
we do not know the extent to which any faithfully represent clinically significant human …

Background: Inherited mutations in the BRCA1 gene may be responsible for almost half of
inherited breast carcinomas. However, somatic (acquired) mutations in BRCA1 have not …

Triple-negative breast cancers are defined by a lack of expression of oestrogen,
progesterone, and ERBB2 receptors. This subgroup accounts for 15% of all types of breast …

Inheritance of one defective BRCA2 allele predisposes humans to breast cancer. To
establish a mouse model for BRCA2-associated breast cancer, we generated mouse …

Germline mutations in BRCA1 and BRCA2 predispose to common human malignancies,
most notably tumors of the breast and ovaries. The proteins encoded by these genes have …