Stimuli-responsive In situ gelling system for nose-to-brain drug delivery
The diagnosis and treatment of neurological ailments always remain an utmost challenge for
research fraternity due to the presence of BBB. The intranasal route appeared as an …
research fraternity due to the presence of BBB. The intranasal route appeared as an …
Polysaccharides in ocular drug delivery
Polysaccharides, such as cellulose, hyaluronic acid, alginic acid, and chitosan, as well as
polysaccharide derivatives, have been successfully used to augment drug delivery in the …
polysaccharide derivatives, have been successfully used to augment drug delivery in the …
Recent advances in antimicrobial nano-drug delivery systems
TX Zong, AP Silveira, JAV Morais, MC Sampaio… - Nanomaterials, 2022 - mdpi.com
Infectious diseases are among the major health issues of the 21st century. The substantial
use of antibiotics over the years has contributed to the dissemination of multidrug resistant …
use of antibiotics over the years has contributed to the dissemination of multidrug resistant …
Recent advances in polymer-based vaginal drug delivery systems
T Osmałek, A Froelich, B Jadach, A Tatarek… - Pharmaceutics, 2021 - mdpi.com
The vagina has been considered a potential drug administration route for centuries. Most of
the currently marketed and investigated vaginal formulations are composed with the use of …
the currently marketed and investigated vaginal formulations are composed with the use of …
Advancing the stimuli response of polymer-based drug delivery systems for ocular disease treatment
DD Nguyen, JY Lai - Polymer Chemistry, 2020 - pubs.rsc.org
The development of efficient therapies for ocular diseases remains a significant challenge
because of the static and dynamic barriers in the eye. A variety of pharmaceutical strategies …
because of the static and dynamic barriers in the eye. A variety of pharmaceutical strategies …
Thermosensitive and mucoadhesive in situ ocular gel for effective local delivery and antifungal activity of itraconazole nanocrystal in the treatment of fungal keratitis
Itraconazole is a lipophilic drug, which limits its absorption for ocular administration. This
study focused on the incorporation of itraconazole into nanocrystalline carrier system with …
study focused on the incorporation of itraconazole into nanocrystalline carrier system with …
Microneedle technology as a new standpoint in agriculture: Treatment and sensing
Preventing plant loss and improving their health status are essential for agricultural industry.
Correspondingly, the deprivation of plants severely impacts our ecological system. As such …
Correspondingly, the deprivation of plants severely impacts our ecological system. As such …
In situ ophthalmic gel forming systems of poloxamer 407 and hydroxypropyl methyl cellulose mixtures for sustained ocular delivery of chloramphenicole: Optimization …
Background Conventional drug delivery systems have some major drawbacks such as low
bioavailability, short residence time and rapid precorneal drainage. An in situ gel drug …
bioavailability, short residence time and rapid precorneal drainage. An in situ gel drug …
Accelerated blood clearance of PEGylated nanoparticles induced by PEG-based pharmaceutical excipients
G Miao, Y He, K Lai, Y Zhao, P He, G Tan… - Journal of Controlled …, 2023 - Elsevier
PEGylated nanomedicines have been extensively developed and applied to cancer therapy.
However, the antitumor efficacy of these nanoparticles is hampered by the accelerated …
However, the antitumor efficacy of these nanoparticles is hampered by the accelerated …
Nasal administration of a temozolomide-loaded thermoresponsive nanoemulsion reduces tumor growth in a preclinical glioblastoma model
LR Michels, FNS Fachel, RS Schuh… - Journal of Controlled …, 2023 - Elsevier
Glioblastoma (GB) is the worst and most common primary brain tumor. Temozolomide
(TMZ), an alkylating agent, is widely used for treating primary and recurrent high-grade …
(TMZ), an alkylating agent, is widely used for treating primary and recurrent high-grade …