Stimuli-responsive In situ gelling system for nose-to-brain drug delivery

M Agrawal, S Saraf, S Saraf, SK Dubey, A Puri… - Journal of Controlled …, 2020 - Elsevier
The diagnosis and treatment of neurological ailments always remain an utmost challenge for
research fraternity due to the presence of BBB. The intranasal route appeared as an …

Polysaccharides in ocular drug delivery

N Dubashynskaya, D Poshina, S Raik, A Urtti… - Pharmaceutics, 2019 - mdpi.com
Polysaccharides, such as cellulose, hyaluronic acid, alginic acid, and chitosan, as well as
polysaccharide derivatives, have been successfully used to augment drug delivery in the …

Recent advances in antimicrobial nano-drug delivery systems

TX Zong, AP Silveira, JAV Morais, MC Sampaio… - Nanomaterials, 2022 - mdpi.com
Infectious diseases are among the major health issues of the 21st century. The substantial
use of antibiotics over the years has contributed to the dissemination of multidrug resistant …

Recent advances in polymer-based vaginal drug delivery systems

T Osmałek, A Froelich, B Jadach, A Tatarek… - Pharmaceutics, 2021 - mdpi.com
The vagina has been considered a potential drug administration route for centuries. Most of
the currently marketed and investigated vaginal formulations are composed with the use of …

Advancing the stimuli response of polymer-based drug delivery systems for ocular disease treatment

DD Nguyen, JY Lai - Polymer Chemistry, 2020 - pubs.rsc.org
The development of efficient therapies for ocular diseases remains a significant challenge
because of the static and dynamic barriers in the eye. A variety of pharmaceutical strategies …

Thermosensitive and mucoadhesive in situ ocular gel for effective local delivery and antifungal activity of itraconazole nanocrystal in the treatment of fungal keratitis

AD Permana, RN Utami, P Layadi, A Himawan… - International journal of …, 2021 - Elsevier
Itraconazole is a lipophilic drug, which limits its absorption for ocular administration. This
study focused on the incorporation of itraconazole into nanocrystalline carrier system with …

Microneedle technology as a new standpoint in agriculture: Treatment and sensing

E Ece, I Eş, F Inci - Materials Today, 2023 - Elsevier
Preventing plant loss and improving their health status are essential for agricultural industry.
Correspondingly, the deprivation of plants severely impacts our ecological system. As such …

In situ ophthalmic gel forming systems of poloxamer 407 and hydroxypropyl methyl cellulose mixtures for sustained ocular delivery of chloramphenicole: Optimization …

IS Kurniawansyah, T Rusdiana, I Sopyan, H Ramoko… - Heliyon, 2020 - cell.com
Background Conventional drug delivery systems have some major drawbacks such as low
bioavailability, short residence time and rapid precorneal drainage. An in situ gel drug …

Accelerated blood clearance of PEGylated nanoparticles induced by PEG-based pharmaceutical excipients

G Miao, Y He, K Lai, Y Zhao, P He, G Tan… - Journal of Controlled …, 2023 - Elsevier
PEGylated nanomedicines have been extensively developed and applied to cancer therapy.
However, the antitumor efficacy of these nanoparticles is hampered by the accelerated …

Nasal administration of a temozolomide-loaded thermoresponsive nanoemulsion reduces tumor growth in a preclinical glioblastoma model

LR Michels, FNS Fachel, RS Schuh… - Journal of Controlled …, 2023 - Elsevier
Glioblastoma (GB) is the worst and most common primary brain tumor. Temozolomide
(TMZ), an alkylating agent, is widely used for treating primary and recurrent high-grade …