Resistance to immune checkpoint therapies by tumour-induced T-cell desertification and exclusion: key mechanisms, prognostication and new therapeutic …

MM Wang, SE Coupland, T Aittokallio… - British Journal of …, 2023 - nature.com
Immune checkpoint therapies (ICT) can reinvigorate the effector functions of anti-tumour T
cells, improving cancer patient outcomes. Anti-tumour T cells are initially formed during their …

[HTML][HTML] Vitreoretinal lymphoma

B Sobolewska, SP Chee, F Zaguia, DA Goldstein… - Cancers, 2021 - mdpi.com
Simple Summary Vitreoretinal lymphoma is a variant of primary CNS lymphoma involving
the retina and/or the vitreous. At the time of presentation, CNS involvement occurs in up to …

The molecular hallmarks of primary and secondary vitreoretinal lymphoma

I Bonzheim, P Sander, J Salmerón-Villalobos… - Blood …, 2022 - ashpublications.org
Vitreoretinal lymphoma (VRL) is a rare subtype of diffuse large B-cell lymphoma (DLBCL)
considered a variant of primary central nervous system lymphoma (PCNSL). The diagnosis …

Oncogenic mutations of MYD88 and CD79B in diffuse large B-cell lymphoma and implications for clinical practice

C Visco, I Tanasi, FM Quaglia, I Ferrarini, C Fraenza… - Cancers, 2020 - mdpi.com
Simple Summary A diagnosis of diffuse large B-cell lymphoma in our therapeutic era should
be implemented by the definition of the cell of origin, additional immunohistochemistry (ie …

Primary vitreoretinal lymphoma: Current diagnostic laboratory tests and new emerging molecular tools

B Melli, P Gentile, D Nicoli, E Farnetti, S Croci, F Gozzi… - Current …, 2022 - mdpi.com
Primary vitreoretinal lymphoma (PVRL), a rare aggressive malignancy primarily involving
the retina and/or the vitreous, is a major diagnostic challenge for clinicians (who commonly …

New insights into immunological therapy for retinal disorders

A Takeda, R Yanai, Y Murakami, M Arima… - Frontiers in …, 2020 - frontiersin.org
In the twentieth century, a conspicuous lack of effective treatment strategies existed for
managing several retinal disorders, including age-related macular degeneration; diabetic …

High-throughput microRNA profiling of vitreoretinal lymphoma: vitreous and serum microRNA profiles distinct from uveitis

T Minezaki, Y Usui, M Asakage, M Takanashi… - Journal of Clinical …, 2020 - mdpi.com
Purpose: Vitreoretinal lymphoma (VRL) is a non-Hodgkin lymphoma of the diffuse large B
cell type (DLBCL), which is an aggressive cancer causing central nervous system related …

Primary CNS lymphoma: update on molecular pathogenesis and therapy

SS Mo, J Cleveland, JL Rubenstein - Leukemia & Lymphoma, 2023 - Taylor & Francis
Primary central nervous system lymphoma (PCNSL) is a rare and aggressive form of extra-
nodal non-Hodgkin lymphoma that as a brain tumor poses a unique set of challenges in …

Cytologic and molecular diagnostics for vitreoretinal lymphoma: current approaches and emerging single-cell analyses

WJ Tan, MM Wang, P Ricciardi-Castagnoli… - Frontiers in Molecular …, 2021 - frontiersin.org
Vitreoretinal lymphoma (VRL) is a rare ocular malignancy that manifests as diffuse large B-
cell lymphoma. Early and accurate diagnosis is essential to prevent mistreatment and to …

Applying single-cell technology in uveal melanomas: current trends and perspectives for improving uveal melanoma metastasis surveillance and tumor profiling

MM Wang, C Chen, MN Lynn, CR Figueiredo… - Frontiers in Molecular …, 2021 - frontiersin.org
Uveal melanoma (UM) is the most common primary adult intraocular malignancy. This rare
but devastating cancer causes vision loss and confers a poor survival rate due to distant …