The testicular spermatozoa of all mammalian species are considered functionally immature
owing to their inability to swim in a progressive manner and engage in productive …

The Ca2+ extrusion function of the four mammalian isoforms of the plasma membrane
calcium ATPases (PMCAs) is well established. There is also ever-increasing detail known of …

PMCA4, a membrane protein, is the major Ca2+ efflux pump in murine sperm where its
deletion leads to a severe loss of hyperactivated motility and to male infertility. We have …

Oviductosomes ((OVS), exosomes/microvesicles), which deliver the Ca 2+ efflux pump,
plasma membrane Ca 2+ ATPase 4 (PMCA4), to sperm are likely to play an important role in …

In mammals, sperm fertilization potential relies on efficient progression within the female
genital tract to reach and fertilize the oocyte. This fundamental property is supported by the …

Sperm are transcriptionally and translationally quiescent and, therefore, rely on the seminal
plasma microenvironment for function, survival and fertilization of the oocyte in the oviduct …

Circular RNA (circRNA) biogenesis requires a backsplicing reaction, promoted by inverted
repeats in cis-flanking sequences and trans factors, such as RNA-binding proteins (RBPs) …

STUDY QUESTIONS Are extracellular vesicles (EVs) in the murine oviduct (oviductosomes,
OVS) conserved in humans and do they play a role in the fertility of Pmca4−/− females …

Acute pancreatitis is a disease associated with inflammation and tissue damage. One
protein that protects against acute injury, including ischemic injury to both the kidney and …

Oviductosomes (OVS) are nano-sized extracellular vesicles secreted in the oviductal luminal
fluid by oviductal epithelial cells and known to be involved in sperm capacitation and fertility …