Technology development in biological research often aims to either increase the number of
cellular features that can be surveyed simultaneously or enhance the resolution at which …

A highly multiplexed cytometric imaging approach, termed co-detection by indexing
(CODEX), is used here to create multiplexed datasets of normal and lupus (MRL/lpr) murine …

Immune responses involve coordination across cell types and tissues. However, studies in
cancer immunotherapy have focused heavily on local immune responses in the tumor …

The immune system is unique in its dynamic interplay between numerous cell types.
However, a system-wide view of how immune cells communicate to protect against disease …

Tubo-ovarian high-grade serous carcinoma (HGSC) is unresponsive to immune checkpoint
blockade despite significant frequencies of exhausted T cells. Here we apply mass …

We have performed an in-depth single-cell phenotypic characterization of high-grade serous
ovarian cancer (HGSOC) by multiparametric mass cytometry (CyTOF). Using a CyTOF …

Salmonella Typhimurium is a causative agent of nontyphoidal salmonellosis, for which there
is a lack of a clinically approved vaccine in humans. As an intracellular pathogen …

High‐dimensional immunoprofiling is essential for studying host response to
immunotherapy, infection, and disease in murine model systems. However, the difficulty of …

Macrophages mediate key antimicrobial responses against intracellular bacterial
pathogens, such as Salmonella enterica. Yet, they can also act as a permissive niche for …

The intracellular bacterial pathogen Francisella tularensis causes serious infectious disease
in humans and animals. Moreover, F. tularensis, a highly infectious pathogen, poses a major …