How eukaryotic transcriptional activators work
M Ptashne - Nature, 1988 - nature.com
How eukaryotic transcriptional activators work Page 1 _N_A_TU_R_E_V_O_L_.
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Three habits of highly effective signaling pathways: principles of transcriptional control by developmental cell signaling
S Barolo, JW Posakony - Genes & development, 2002 - genesdev.cshlp.org
Seven major cell–cell signaling pathways—Wnt, TGF-ß, Hedgehog (Hh), receptor tyrosine
kinase (RTK), nuclear receptor, Jak/STAT, and Notch—control the vast majority of cell fate …
kinase (RTK), nuclear receptor, Jak/STAT, and Notch—control the vast majority of cell fate …
GAL4-VP16 is an unusually potent transcriptional activator
I Sadowski, J Ma, S Triezenberg, M Ptashne - Nature, 1988 - nature.com
Recent work has defined a class of transcriptional activators1–5, members of which activate
transcription in yeast, plant, insect and mammalian cells6–9. These proteins contain two …
transcription in yeast, plant, insect and mammalian cells6–9. These proteins contain two …
MeCP2 is a transcriptional repressor with abundant binding sites in genomic chromatin
MeCP2 is an abundant mammalian protein that binds to methylated CpG. We have found
that native and recombinant MeCP2 repress transcription in vitro from methylated promoters …
that native and recombinant MeCP2 repress transcription in vitro from methylated promoters …
TGFβ signals through a heteromeric protein kinase receptor complex
Transforming growth factor p (TGFfl) binds with high affinity to the type II receptor, a
transmembrane protein with a cytoplasmic serine/threonine kinase domain. We show that …
transmembrane protein with a cytoplasmic serine/threonine kinase domain. We show that …
Purification and biochemical heterogeneity of the mammalian SWI‐SNF complex.
We have purified distinct complexes of nine to 12 proteins [referred to as BRG1‐associated
factors (BAFs)] from several mammalian cell lines using an antibody to the SWI2‐SNF2 …
factors (BAFs)] from several mammalian cell lines using an antibody to the SWI2‐SNF2 …
Nucleosome disruption and enhancement of activator binding by a human SW1/SNF complex
H Kwon, AN Imbalzano, PA Khavari, RE Kingston… - Nature, 1994 - nature.com
CHROMATIN structure can affect the transcriptional activity of eukaryotic structural genes by
blocking access of sequence-specific activator proteins (activators) to their promoter-binding …
blocking access of sequence-specific activator proteins (activators) to their promoter-binding …
Stimulation of GAL4 derivative binding to nucleosomal DNA by the yeast SWI/SNF complex
The SWI/SNF protein complex is required for the enhancement of transcription by many
transcriptional activators in yeast. Here it is shown that the purified SWI/SNF complex is …
transcriptional activators in yeast. Here it is shown that the purified SWI/SNF complex is …
Acetylation of histone H4 by Esa1 is required for DNA double-strand break repair
AW Bird, DY Yu, MG Pray-Grant, Q Qiu, KE Harmon… - Nature, 2002 - nature.com
Although the acetylation of histones has a well-documented regulatory role in transcription,,,,
its role in other chromosomal functions remains largely unexplored. Here we show that …
its role in other chromosomal functions remains largely unexplored. Here we show that …
DNA recognition by GAL4: structure of a protein-DNA complex
R Marmorstein, M Carey, M Ptashne, SC Harrison - Nature, 1992 - nature.com
A specific DNA complex of the 65-residue, N-terminal fragment of the yeast transcriptional
activator, GAL4, has been analysed at 2.7 Å resolution by X-ray crystallography. The protein …
activator, GAL4, has been analysed at 2.7 Å resolution by X-ray crystallography. The protein …