The global burden of snakebite: a literature analysis and modelling based on regional estimates of envenoming and deaths

A Kasturiratne, AR Wickremasinghe, N de Silva… - PLoS …, 2008 - journals.plos.org
Background Envenoming resulting from snakebites is an important public health problem in
many tropical and subtropical countries. Few attempts have been made to quantify the …

Skeletal muscle degeneration induced by venom phospholipases A2: insights into the mechanisms of local and systemic myotoxicity

JM Gutiérrez, CL Ownby - Toxicon, 2003 - Elsevier
Local and systemic skeletal muscle degeneration is a common consequence of
envenomations due to snakebites and mass bee attacks. Phospholipases A2 (PLA2) are …

[图书][B] Handbook of venoms and toxins of reptiles

SP Mackessy - 2016 - taylorfrancis.com
The Handbook of Venoms and Toxins of Reptiles offers" one-stop shopping" to all biologists,
biochemists, toxicologists, physicians, clinicians, and epidemiologists, and informed …

Hemorrhage induced by snake venom metalloproteinases: biochemical and biophysical mechanisms involved in microvessel damage

JM Gutiérrez, A Rucavado, T Escalante, C Díaz - Toxicon, 2005 - Elsevier
Zinc-dependent metalloproteinases are responsible for the hemorrhagic activity
characteristic of viperid snake venoms. Snake venom metalloproteinases (SVMPs) are …

Snake Venomics of the Lancehead Pitviper Bothrops asper: Geographic, Individual, and Ontogenetic Variations

A Alape-Girón, L Sanz, J Escolano… - Journal of proteome …, 2008 - ACS Publications
We report the comparative proteomic characterization of the venoms of adult and newborn
specimens of the lancehead pitviper Bothrops asper from two geographically isolated …

Key events in microvascular damage induced by snake venom hemorrhagic metalloproteinases

T Escalante, A Rucavado, JW Fox, JM Gutiérrez - Journal of proteomics, 2011 - Elsevier
Hemorrhage is one of the most significant effects in envenomings induced by viperid
snakebites. Damage to the microvasculature, induced by snake venom metalloproteinases …

An overview of lysine-49 phospholipase A2 myotoxins from crotalid snake venoms and their structural determinants of myotoxic action

B Lomonte, Y Angulo, L Calderón - Toxicon, 2003 - Elsevier
In 1984, the first venom phospholipase A2 (PLA2) with a lysine substituting for the highly
conserved aspartate 49 was discovered, in the North American crotalid snake Agkistrodon p …

Epidemiological, clinical and therapeutic aspects of Bothrops asper bites

R Otero-Patino - Toxicon, 2009 - Elsevier
Bothrops asper inflicts the majority of snakebites in Central America and in the northern
regions of South America, mostly affecting young agricultural workers in rural settings. This …

Older age and time to medical assistance are associated with severity and mortality of snakebites in the Brazilian Amazon: a case-control study

EL Feitosa, VS Sampaio, JL Salinas, AM Queiroz… - PLoS one, 2015 - journals.plos.org
The Amazon region reports the highest incidence of snakebite envenomings in Brazil. We
aimed to describe the epidemiology of snakebites in the state of Amazonas and to …

Experimental pathology of local tissue damage induced by Bothrops asper snake venom

JM Gutiérrez, A Rucavado, F Chaves, C Díaz… - Toxicon, 2009 - Elsevier
Envenomations by Bothrops asper are often associated with complex and severe local
pathological manifestations, including edema, blistering, dermonecrosis, myonecrosis and …