[HTML][HTML] Benzodiazepines: uses, dangers, and clinical considerations

AN Edinoff, CA Nix, J Hollier, CE Sagrera… - Neurology …, 2021 - mdpi.com
Benzodiazepines (BZDs) are among one of the most widely prescribed drug classes in the
United States. BZDs are a class of psychoactive drugs known for their depressant effect on …

Treatment of benzodiazepine dependence

M Soyka - New England Journal of Medicine, 2017 - Mass Medical Soc
Treatment of Benzodiazepine Dependence | NEJM Skip to main content NEJM Group Follow Us
Facebook Twitter Instagram YouTube LinkedIn Prepare to become a physician, build your …

Anxiety disorders and GABA neurotransmission: a disturbance of modulation

P Nuss - Neuropsychiatric disease and treatment, 2015 - Taylor & Francis
Lines of evidence coming from many branches of neuroscience indicate that anxiety
disorders arise from a dysfunction in the modulation of brain circuits which regulate …

[HTML][HTML] GABAA receptor subtypes and benzodiazepine use, misuse, and abuse

E Engin - Frontiers in Psychiatry, 2023 - frontiersin.org
Benzodiazepines have been in use for over half a century. While they remain highly
prescribed, their unfavorable side-effect profile and abuse liability motivated a search for …

[HTML][HTML] To approach or avoid: an introductory overview of the study of anxiety using rodent assays

M La-Vu, BC Tobias, PJ Schuette… - Frontiers in behavioral …, 2020 - frontiersin.org
Anxiety is a widely studied phenomenon in behavioral neuroscience, but the recent
literature lacks an overview of the major conceptual framework underlying anxiety research …

[HTML][HTML] Management of benzodiazepine misuse and dependence

J Brett, B Murnion - Australian prescriber, 2015 - ncbi.nlm.nih.gov
Management of benzodiazepine misuse and dependence - PMC Back to Top Skip to main
content NIH NLM Logo Access keys NCBI Homepage MyNCBI Homepage Main Content Main …

Long-term use of benzodiazepines: definitions, prevalence and usage patterns–a systematic review of register-based studies

TAT Kurko, LK Saastamoinen, S Tähkäpää… - European …, 2015 - cambridge.org
BackgroundNumerous treatment guidelines recommend that long-term use of
benzodiazepines (BZD) should be avoided primarily due to development of tolerance and a …

Benzodiazepine harm: how can it be reduced?

M Lader - British journal of clinical pharmacology, 2014 - Wiley Online Library
The benzodiazepines (BZDs) are anxiolytics, hypnotics, anticonvulsants, muscle‐relaxants
and induce anaesthesia. Adverse effects comprise sedation subjectively and cognitive and …

[HTML][HTML] Understanding the mechanism of action and clinical effects of neuroactive steroids and GABAergic compounds in major depressive disorder

AJ Cutler, GW Mattingly, V Maletic - Translational Psychiatry, 2023 - nature.com
The pathophysiology of major depressive disorder (MDD) is thought to result from impaired
connectivity between key brain networks. Gamma-aminobutyric acid (GABA) is the key …

A systematic review of interventions to deprescribe benzodiazepines and other hypnotics among older people

E Reeve, M Ong, A Wu, J Jansen, M Petrovic… - European journal of …, 2017 - Springer
Purpose Benzodiazepines are effective medicines for insomnia and anxiety but are
commonly used beyond recommended treatment time frames, which may lead to adverse …