Bacterial Metallostasis: Metal Sensing, Metalloproteome Remodeling, and Metal Trafficking
DA Capdevila, JJ Rondón, KA Edmonds… - Chemical …, 2024 - ACS Publications
Transition metals function as structural and catalytic cofactors for a large diversity of proteins
and enzymes that collectively comprise the metalloproteome. Metallostasis considers all …
and enzymes that collectively comprise the metalloproteome. Metallostasis considers all …
Adaptive laboratory evolution recruits the promiscuity of succinate semialdehyde dehydrogenase to repair different metabolic deficiencies
H He, PA Gómez-Coronado, J Zarzycki… - Nature …, 2024 - nature.com
Promiscuous enzymes often serve as the starting point for the evolution of novel functions.
Yet, the extent to which the promiscuity of an individual enzyme can be harnessed several …
Yet, the extent to which the promiscuity of an individual enzyme can be harnessed several …
A bacterial transcription activator dedicated to the expression of the enzyme catalyzing the first committed step in fatty acid biosynthesis
Y Xu, Z Lin, J Hou, K Ye, S Han, Y Liang… - Nucleic Acids …, 2024 - academic.oup.com
Abstract Acetyl-CoA carboxylase (ACCase) catalyzes the first committed and rate-limiting
step of de novo fatty acid synthesis (FAS). Although this step is tightly regulated, regulators …
step of de novo fatty acid synthesis (FAS). Although this step is tightly regulated, regulators …
A sensitive PnpR-based biosensor for p-nitrophenol detection
W Shuxin, C Sibo, Y Hang, Z Xiaoran, C Zhongli… - International Journal of …, 2024 - Elsevier
A common aromatic and phenolic pollutant, p-nitrophenol (PNP), is widely used in various
industry and has serious risk to the environmental health. Biosensors have been extensively …
industry and has serious risk to the environmental health. Biosensors have been extensively …
The LysR‐type transcriptional regulator LelA co‐regulates various effectors in different Legionella species
N Shapira, T Zusman, G Segal - Molecular Microbiology, 2024 - Wiley Online Library
The intracellular pathogen Legionella pneumophila translocates more than 300 effector
proteins into its host cells. The expression levels of the genes encoding these effectors are …
proteins into its host cells. The expression levels of the genes encoding these effectors are …
[HTML][HTML] The LysR family transcriptional regulator ORF-L16 regulates spinosad biosynthesis in Saccharopolyspora spinosa
X Mu, R Lei, S Yan, Z Deng, R Liu, T Liu - Synthetic and Systems …, 2024 - Elsevier
Spinosad, a potent broad-spectrum bioinsecticide produced by Saccharopolyspora spinosa,
has significant market potential. Despite its effectiveness, the regulatory mechanisms of …
has significant market potential. Despite its effectiveness, the regulatory mechanisms of …