[HTML][HTML] Metabolic-associated fatty liver disease and lipoprotein metabolism
J Heeren, L Scheja - Molecular metabolism, 2021 - Elsevier
Background Non-alcoholic fatty liver disease, or as recently proposed 'metabolic-associated
fatty liver disease'(MAFLD), is characterized by pathological accumulation of triglycerides …
fatty liver disease'(MAFLD), is characterized by pathological accumulation of triglycerides …
[HTML][HTML] Hepatic lipid droplets: A balancing act between energy storage and metabolic dysfunction in NAFLD
DG Mashek - Molecular metabolism, 2021 - Elsevier
Background Non-alcoholic fatty liver disease (NAFLD) is defined by the abundance of lipid
droplets (LDs) in hepatocytes. While historically considered simply a depot for energy …
droplets (LDs) in hepatocytes. While historically considered simply a depot for energy …
Lipid droplets and liver disease: from basic biology to clinical implications
NL Gluchowski, M Becuwe, TC Walther… - Nature reviews …, 2017 - nature.com
Lipid droplets are dynamic organelles that store neutral lipids during times of energy excess
and serve as an energy reservoir during deprivation. Many prevalent metabolic diseases …
and serve as an energy reservoir during deprivation. Many prevalent metabolic diseases …
Lipid droplet biogenesis
TC Walther, J Chung… - Annual review of cell and …, 2017 - annualreviews.org
Lipid droplets (LDs) are ubiquitous organelles that store neutral lipids for energy or
membrane synthesis and act as hubs for metabolic processes. Cells generate LDs de novo …
membrane synthesis and act as hubs for metabolic processes. Cells generate LDs de novo …
Triglyceride synthesis by DGAT1 protects adipocytes from lipid-induced ER stress during lipolysis
C Chitraju, N Mejhert, JT Haas, LG Diaz-Ramirez… - Cell metabolism, 2017 - cell.com
Triglyceride (TG) storage in adipose tissue provides the major reservoir for metabolic energy
in mammals. During lipolysis, fatty acids (FAs) are hydrolyzed from adipocyte TG stores and …
in mammals. During lipolysis, fatty acids (FAs) are hydrolyzed from adipocyte TG stores and …
[HTML][HTML] Acyl-CoA: diacylglycerol acyltransferase: Properties, physiological roles, metabolic engineering and intentional control
Acyl-CoA: diacylglycerol acyltransferase (DGAT, EC 2.3. 1.20) catalyzes the last reaction in
the acyl-CoA-dependent biosynthesis of triacylglycerol (TAG). DGAT activity resides mainly …
the acyl-CoA-dependent biosynthesis of triacylglycerol (TAG). DGAT activity resides mainly …
Lipid droplet biogenesis
Lipid droplets (LDs) are found in most cells, where they play central roles in energy and
membrane lipid metabolism. The de novo biogenesis of LDs is a fascinating, yet poorly …
membrane lipid metabolism. The de novo biogenesis of LDs is a fascinating, yet poorly …
Role of DGAT enzymes in triacylglycerol metabolism
B Bhatt-Wessel, TW Jordan, JH Miller, L Peng - Archives of biochemistry …, 2018 - Elsevier
The esterification of a fatty acyl moiety to diacylglycerol to form triacylglycerol (TAG) is
catalysed by two diacylglycerol O-acyltransferases (DGATs) encoded by genes belonging to …
catalysed by two diacylglycerol O-acyltransferases (DGATs) encoded by genes belonging to …
The triglyceride synthesis enzymes DGAT1 and DGAT2 have distinct and overlapping functions in adipocytes
Mammals store metabolic energy as triacylglycerols (TGs) in adipose tissue. TG synthesis is
catalyzed by the evolutionarily unrelated acyl-CoA: diacylglycerol acyltransferase (DGAT) …
catalyzed by the evolutionarily unrelated acyl-CoA: diacylglycerol acyltransferase (DGAT) …
Mammalian triacylglycerol metabolism: synthesis, lipolysis, and signaling
RA Coleman, DG Mashek - Chemical reviews, 2011 - ACS Publications
Triacylglycerol (TAG) is the primary unit of energy storage in eukaryotic cells. TAG comprises
more than 90% of the content of white adipocytes, and TAG synthesis is essential in …
more than 90% of the content of white adipocytes, and TAG synthesis is essential in …