Background Recent progress in understanding the genetic basis of breast cancer and
widely publicized reports of celebrities undergoing risk‐reducing mastectomy (RRM) have …

Ovarian cancer (OC) is the most lethal gynaecological malignancy. The search for a widely
affordable and accessible screening strategy to reduce mortality from OC is still ongoing …

Background Options for women at high risk for breast cancer include surveillance,
chemoprevention, and prophylactic mastectomy. The data on the outcomes for surveillance …

Background. Although genetic testing for breast cancer risk is clinically available, its impact
on health-related behaviors is unknown. This study examined prophylactic surgery and …

ContextWomen with BRCA1-or BRCA2-associated breast cancer are at increased risk for
contralateral breast cancer and ovarian cancer and therefore may consider secondary …

At least 10% of ovarian tumors are hereditary and associated with highly penetrant,
autosomal, dominant genetic predisposition. Three clinical manifestations of hereditary …

Background: Patients with a history of carcinoma of one breast have an estimated risk of
0.5% to 0.75% per year of developing a contralateral breast cancer. This risk prompts many …

Background: For BRCA1 or BRCA2 mutation carriers, decision analysis indicates that
prophylactic surgery or chemoprevention leads to better survival than surveillance alone …

Health-related quality of life is an important issue in the treatment of breast cancer and
health-state utility values are essential for cost–utility analysis. A literature review was …

OBJECTIVES: To examine trends in rates of elective bilateral salpingo-oophorectomy in the
United States and to assess the association of perioperative complications with elective …