Depression is a risk factor for Alzheimer's (AD) and cardiovascular diseases (CVD).
Therefore, depression treatment restricts its deteriorating effects on mood, memory and CV …

Exposure to chronic social isolation (CSIS) and synapse dysfunction have been implicated
in the etiology of major depressive disorder (MDD). Fluoxetine (Flx) has been widely used to …

Parkinson's disease (PD) is a gradual deterioration of dopaminergic neurons, leading to
motor impairments. Social isolation (SI), a recognized stressor, has recently gained attention …

Hypercortisolemia is one of the clinical features found in depressed patients. This clinical
feature has been mimicked in animal studies via application of exogenous corticosterone …

Background: Alzheimer's disease (AD) is a neurodegenerative disease that leads to memory
loss. It is characterized by deposition of Beta-amyloid peptides (Aβ), accumulation of …

Future missions to Mars will expose astronauts to several physical and psychological
challenges, including exposure to space radiation (SR) and periods of social isolation (SI) …

Chronic social isolation (CSIS)–induced alternation in synaptic and mitochondrial function of
specific brain regions is associated with major depressive disorder (MDD). Despite the wide …

Adult neurogenesis—the formation and functional integration of adult-generated neurons—
remains a hot neuroscience topic. Decades of research have identified numerous …

Olanzapine (Olz) is an atypical antipsychotic used to treat depression, anxiety and
schizophrenia, which can be caused by chronic psychosocial stress. c-Fos protein …

Future NASA missions will require astronauts to travel farther and spend longer durations in
space than ever before. This will also expose astronauts to longer periods of several …