CD8+ T cells in HIV control, cure and prevention
HIV infection can be effectively treated by lifelong administration of combination antiretroviral
therapy, but an effective vaccine will likely be required to end the HIV epidemic. Although the …
therapy, but an effective vaccine will likely be required to end the HIV epidemic. Although the …
Recommendations for measuring HIV reservoir size in cure-directed clinical trials
M Abdel-Mohsen, D Richman, RF Siliciano… - Nature medicine, 2020 - nature.com
Therapeutic strategies are being clinically tested either to eradicate latent HIV reservoirs or
to achieve virologic control in the absence of antiretroviral therapy. Attaining this goal will …
to achieve virologic control in the absence of antiretroviral therapy. Attaining this goal will …
The latent reservoir of inducible, infectious HIV-1 does not decrease despite decades of antiretroviral therapy
NF McMyn, J Varriale, EJ Fray… - The Journal of …, 2023 - Am Soc Clin Investig
HIV-1 persists in a latent reservoir in resting CD4+ T cells despite antiretroviral therapy
(ART). The reservoir decays slowly over the first 7 years of ART (t 1/2= 44 months). However …
(ART). The reservoir decays slowly over the first 7 years of ART (t 1/2= 44 months). However …
Engaging innate immunity in HIV-1 cure strategies
Combination antiretroviral therapy (ART) can block multiple stages of the HIV-1 life cycle to
prevent progression to AIDS in people living with HIV-1. However, owing to the persistence …
prevent progression to AIDS in people living with HIV-1. However, owing to the persistence …
Current status of latency reversing agents facing the heterogeneity of HIV-1 cellular and tissue reservoirs
One of the most explored therapeutic approaches aimed at eradicating HIV-1 reservoirs is
the “shock and kill” strategy which is based on HIV-1 reactivation in latently-infected cells …
the “shock and kill” strategy which is based on HIV-1 reactivation in latently-infected cells …
[HTML][HTML] The paradox of HIV blood–brain barrier penetrance and antiretroviral drug delivery deficiencies
HIV attacks the body's immune cells, frequently compromises the integrity of the blood–brain
barrier (BBB), and infects the CNS in the early stages of infection. Dysfunction of the BBB …
barrier (BBB), and infects the CNS in the early stages of infection. Dysfunction of the BBB …
HIV rebound is predominantly fueled by genetically identical viral expansions from diverse reservoirs
Viral rebound upon stopping combined antiretroviral therapy poses a major barrier toward
an HIV cure. Cellular and anatomical sources responsible for reinitiating viral replication …
an HIV cure. Cellular and anatomical sources responsible for reinitiating viral replication …
Recommendations for analytical antiretroviral treatment interruptions in HIV research trials—report of a consensus meeting
B Julg, L Dee, J Ananworanich, DH Barouch, K Bar… - The lancet HIV, 2019 - thelancet.com
Analytical antiretroviral treatment interruption (ATI) is an important feature of HIV research,
seeking to achieve sustained viral suppression in the absence of antiretroviral therapy (ART) …
seeking to achieve sustained viral suppression in the absence of antiretroviral therapy (ART) …
In vivo dynamics of the latent reservoir for HIV-1: new insights and implications for cure
JD Siliciano, RF Siliciano - Annual Review of Pathology …, 2022 - annualreviews.org
Although antiretroviral therapy (ART) can reduce viremia to below the limit of detection and
allow persons living with HIV-1 (PLWH) to lead relatively normal lives, viremia rebounds …
allow persons living with HIV-1 (PLWH) to lead relatively normal lives, viremia rebounds …
Profound phenotypic and epigenetic heterogeneity of the HIV-1-infected CD4+ T cell reservoir
Understanding the complexity of the long-lived HIV reservoir during antiretroviral therapy
(ART) remains a considerable impediment in research towards a cure for HIV. To address …
(ART) remains a considerable impediment in research towards a cure for HIV. To address …