Despite the high prevalence of male infertility, very little is known about its etiology. In recent
years however, advances in gene sequencing technology have enabled us to identify a …

Asthenozoospermia (AZS), defined by reduced motility or absent sperm motility, is one of the
main causes of male infertility. This condition may be divided into isolated AZS in the …

Asthenoteratozoospermia characterized by multiple morphological abnormalities of the
flagella (MMAF) has been identified as a sub-type of male infertility. Recent progress has …

The T-shaped radial spoke (RS) is a protein complex attached to the A microtubule of the
outer doublet microtubules, and it extends toward the central pair (CP). It modulates the beat …

STUDY QUESTION What are the causative genetic variants in patients with male infertility
due to severe sperm motility disorders? SUMMARY ANSWER We identified high confidence …

Sperm carries male genetic information, and flagella help move the sperm to reach oocytes.
When the ultrastructure of the flagella is abnormal, the sperm is unable to reach the oocyte …

Abstract Infertility affects 8–12% of couples globally, and the male factor is a primary cause
in~ 50% of couples. Male infertility is a multifactorial reproductive disorder, which can be …

Asthenozoospermia, defined by the absence or reduction of sperm motility, constitutes the
most frequent cause of human male infertility. This pathological condition is caused by …

Motile cilia and flagellar defects can result in primary ciliary dyskinesia, which is a
multisystemic genetic disorder that affects roughly 1: 10 000 individuals. The nexin-dynein …

Male infertility is an important health concern that is expected to have a major genetic
etiology. Although high-throughput sequencing has linked gene defects to more than 50% of …