Different cell channels and transporters tightly regulate cytoplasmic levels and the
intraorganelle distribution of cations. Perturbations in these processes lead to human …

Krüppel-like zinc finger proteins form one of the largest families of transcription factors. They
function as key regulators of embryonic development and a wide range of other …

G-protein coupled receptors (GPCRs) govern the physiological response to stimuli by
modulating the activity of downstream effectors, including ion channels. TRPM3 is an ion …

Cells need to sense their mechanical environment during the growth of developing tissues
and maintenance of adult tissues. The concept of force-sensing mechanisms that act …

Osteoarthritis (OA) is one of the most prevalent joint disorders associated with the
degradation of articular cartilage and an abnormal mechanical microenvironment …

Already for centuries, humankind is driven to understand the physiological and pathological
mechanisms that occur in our brains. Today, we know that ion channels play an essential …

Background Single-cell transcriptomes from dissociated tissues provide insights into cell
types and their gene expression and may harbor additional information on spatial position …

First discovered in a light-sensitive retinal mutant of Drosophila, the transient receptor
potential (TRP) superfamily of non-selective cation channels serve as polymodal cellular …

Background The primary cilium, a microtubule-based cellular organelle present in certain
kidney cells, functions as a mechano-sensor to monitor fluid flow in addition to various other …

Vectors of infectious disease include several species of Aedes mosquitoes. The life cycle of
Aedes aegypti, the yellow fever mosquito, consists of a terrestrial adult and an aquatic larval …