HE4 as a Biomarker for Endometrial Cancer

R Behrouzi, CE Barr, EJ Crosbie - Cancers, 2021 - mdpi.com
Simple Summary There are currently no blood biomarkers approved for routine clinical use
in endometrial cancer. Serum human epididymis protein 4 (HE4) is significantly higher in …

The role of biomarkers in endometrial cancer and hyperplasia: a literature review

S Hutt, A Tailor, P Ellis, A Michael… - Acta …, 2019 - Taylor & Francis
Introduction: Endometrial cancer is the most common gynaecological cancer and its
incidence is rising due to increasing obesity rates. We are also seeing an increasing trend of …

Ovarian cancer recurrence and early detection: may HE4 play a key role in this open challenge? A systematic review of literature

S Capriglione, D Luvero, F Plotti, C Terranova… - Medical Oncology, 2017 - Springer
Despite the improvement in overall survival for ovarian cancer (OC) patients, a fraction of
patients with advanced-stage disease fails to respond to primary therapy and relapses in …

[HTML][HTML] Endometrial cancer: A systematic review of HE4, REM and REM-B

M Degez, H Caillon, A Chauviré-Drouard, M Leroy… - Clinica chimica acta, 2021 - Elsevier
Introduction Endometrial cancer, one of the most frequent pelvic gynecologic cancer
worldwide, currently has no biomarker used to assess it in daily practice. Nonetheless …

HE4 is superior to CA125 in the detection of recurrent disease in high-risk endometrial cancer patients

K Abbink, PLM Zusterzeel, AJ Geurts-Moespot… - Tumor …, 2018 - journals.sagepub.com
Objective: To date, biomarkers are not routinely used in endometrial cancer diagnosis,
prognosis, and follow-up. The purpose of this study was to evaluate whether serum HE4 was …

Serum HE4 and CA125 combined to predict and monitor recurrence of type II endometrial carcinoma

Q Quan, Q Liao, W Yin, S Zhou, S Gong, X Mu - Scientific Reports, 2021 - nature.com
There is no recognized serum biomarker to predict the recurrence of endometrial carcinoma
(EC). We aimed to explore serum human epididymis protein 4 (HE4) and cancer antigen …

Beyond the biomarker: understanding the diverse roles of human epididymis protein 4 in the pathogenesis of epithelial ovarian cancer

NE James, C Chichester, JR Ribeiro - Frontiers in oncology, 2018 - frontiersin.org
Human epididymis protein 4 (HE4) is an important clinical biomarker used for the detection
of epithelial ovarian cancer (EOC). While much is known about the predictive power of HE4 …

Liquid biopsy for monitoring EC patients: towards personalized treatment

R Pineiro-Perez, M Abal, L Muinelo-Romay - Cancers, 2022 - mdpi.com
Simple Summary Although the field of liquid biopsy is clearly having an effect on other
tumour types, in endometrial cancer (EC) there is important work to do to implement the …

[HTML][HTML] HE4 and CA125 as preoperative risk stratifiers for lymph node metastasis in endometrioid carcinoma of the endometrium: a retrospective study in a cohort with …

SA O'Toole, Y Huang, L Norris, MP Foley… - Gynecologic …, 2021 - Elsevier
Objectives To investigate whether HE4 and CA125 could identify endometrioid
adenocarcinoma patients who might most benefit from full staging surgery with …

Prognostic values of human epididymis protein 4 expression in patients with endometrial cancer: A systematic review and meta‐analysis

L Han, Y Han, P Yan - Journal of Obstetrics and Gynaecology …, 2022 - Wiley Online Library
Background There is no consensus on the correlation between human epididymis protein 4
(HE4) and prognosis of endometrial cancer (EC). Therefore, we performed a meta‐analysis …